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A safe, effective and adaptable live-attenuated SARS-CoV-2 vaccine to reduce disease and transmission using one-to-stop genome modifications.
Schön J, Barut GT, Trüeb BS, Halwe NJ, Berenguer Veiga I, Kratzel A, Ulrich L, Kelly JN, Brügger M, Wylezich C, Taddeo A, Aguiar Moreira E, Túrós D, Grau-Roma L, Ahrens AK, Schlottau K, Britzke T, Breithaupt A, Corleis B, Kochmann J, Oliveira Esteves BI, Almeida L, Thomann L, Devisme C, Stalder H, Steiner S, Ochsenbein S, Schmied K, Labroussaa F, Jores J, V'kovski P, Cmiljanovic V, Alves MP, Benarafa C, Ebert N, Hoffmann D, Beer M, Thiel V. Schön J, et al. Among authors: thiel v. Nat Microbiol. 2024 Aug;9(8):2099-2112. doi: 10.1038/s41564-024-01755-1. Epub 2024 Jul 12. Nat Microbiol. 2024. PMID: 38997518 Free PMC article.
The Substitutions L50F, E166A, and L167F in SARS-CoV-2 3CLpro Are Selected by a Protease Inhibitor In Vitro and Confer Resistance To Nirmatrelvir.
Jochmans D, Liu C, Donckers K, Stoycheva A, Boland S, Stevens SK, De Vita C, Vanmechelen B, Maes P, Trüeb B, Ebert N, Thiel V, De Jonghe S, Vangeel L, Bardiot D, Jekle A, Blatt LM, Beigelman L, Symons JA, Raboisson P, Chaltin P, Marchand A, Neyts J, Deval J, Vandyck K. Jochmans D, et al. Among authors: thiel v. mBio. 2023 Feb 28;14(1):e0281522. doi: 10.1128/mbio.02815-22. Epub 2023 Jan 10. mBio. 2023. PMID: 36625640 Free PMC article.
Dynamics of antibody titers to SARS-CoV-2 and clinical outcomes after sotrovimab pre-exposure prophylaxis early after allogeneic hematopoietic stem cell transplantation.
Capoferri G, Walti CS, Urwyler P, Ragozzino S, Passweg JR, Halter J, Battegay M, Baettig V, Weisser M, Arnold B, Morin B, Guetlin Y, Torres DA, Barut GT, Thiel V, Egli A, Drexler B, Khanna N. Capoferri G, et al. Among authors: thiel v. Bone Marrow Transplant. 2023 May;58(5):597-599. doi: 10.1038/s41409-023-01936-2. Epub 2023 Feb 16. Bone Marrow Transplant. 2023. PMID: 36797421 Free PMC article. No abstract available.
Anti-SARS-CoV-2 total immunoglobulin and neutralising antibody responses in healthy blood donors throughout the COVID-19 pandemic: a longitudinal observational study.
Gütlin Y, Albertos Torres D, Gensch A, Schlotterbeck AK, Stöger L, Heller S, Infanti L, Barut GT, Thiel V, Leuzinger K, Hirsch HH, Buser A, Egli A. Gütlin Y, et al. Among authors: thiel v. Swiss Med Wkly. 2024 Jul 1;154:3408. doi: 10.57187/s.3408. Swiss Med Wkly. 2024. PMID: 39137369 Free article.
Mosquito-independent milk-associated transmission of zoonotic Wesselsbron virus in sheep.
Zimoch M, Grau-Roma L, Liniger M, Donzé N, Godel A, Escribano D, Trüeb BS, Pramateftaki P, Torres-Puig S, Cerón JJ, Thiel V, Jores J, Summerfield A, Ruggli N, Benarafa C, García-Nicolás O. Zimoch M, et al. Among authors: thiel v. PLoS Pathog. 2024 Dec 9;20(12):e1012751. doi: 10.1371/journal.ppat.1012751. eCollection 2024 Dec. PLoS Pathog. 2024. PMID: 39652585 Free PMC article.
An updated framework for SARS-CoV-2 variants reflects the unpredictability of viral evolution.
Subissi L, Otieno JR, Worp N, Attar Cohen H, Oude Munnink BB, Abu-Raddad LJ, Alm E, Barakat A, Barclay WS, Bhiman JN, Caly L, Chand M, Chen M, Cullinane A, de Oliveira T, Drosten C, Druce J, Effler P, El Masry I, Faye A, Ghedin E, Grant R, Haagmans BL, Happi C, Herring BL, Hodcroft EB, Ikejezie J, Katawera V, Kassamali ZA, Leo YS, Leung GM, Kondor RJ, Marklewitz M, Mendez-Rico J, Melhem NM, Munster V, Nahapetyan K, Naindoo D, Oh DY, Peacock TP, Peiris M, Peng Z, Poon LLM, Rambaut A, Saha S, Shen Y, Siqueira MM, Volz E, Tessema SK, Thiel V, Triki H, van der Werf S, von Eije K, Cunningham J, Koopmans MPG, von Gottberg A, Agrawal A, Van Kerkhove MD. Subissi L, et al. Among authors: thiel v. Nat Med. 2024 Sep;30(9):2400-2403. doi: 10.1038/s41591-024-02949-0. Nat Med. 2024. PMID: 38720002 No abstract available.
Continuous population-level monitoring of SARS-CoV-2 seroprevalence in a large European metropolitan region.
Emmenegger M, De Cecco E, Lamparter D, Jacquat RPB, Riou J, Menges D, Ballouz T, Ebner D, Schneider MM, Morales IC, Doğançay B, Guo J, Wiedmer A, Domange J, Imeri M, Moos R, Zografou C, Batkitar L, Madrigal L, Schneider D, Trevisan C, Gonzalez-Guerra A, Carrella A, Dubach IL, Xu CK, Meisl G, Kosmoliaptsis V, Malinauskas T, Burgess-Brown N, Owens R, Hatch S, Mongkolsapaya J, Screaton GR, Schubert K, Huck JD, Liu F, Pojer F, Lau K, Hacker D, Probst-Müller E, Cervia C, Nilsson J, Boyman O, Saleh L, Spanaus K, von Eckardstein A, Schaer DJ, Ban N, Tsai CJ, Marino J, Schertler GFX, Ebert N, Thiel V, Gottschalk J, Frey BM, Reimann RR, Hornemann S, Ring AM, Knowles TPJ, Puhan MA, Althaus CL, Xenarios I, Stuart DI, Aguzzi A. Emmenegger M, et al. Among authors: thiel v. iScience. 2023 Feb 17;26(2):105928. doi: 10.1016/j.isci.2023.105928. Epub 2023 Jan 4. iScience. 2023. PMID: 36619367 Free PMC article.
Pharmacological inhibition of bromodomain and extra-terminal proteins induces an NRF-2-mediated antiviral state that is subverted by SARS-CoV-2 infection.
Mhlekude B, Postmus D, Stenzel S, Weiner J 3rd, Jansen J, Zapatero-Belinchón FJ, Olmer R, Richter A, Heinze J, Heinemann N, Mühlemann B, Schroeder S, Jones TC, Müller MA, Drosten C, Pich A, Thiel V, Martin U, Niemeyer D, Gerold G, Beule D, Goffinet C. Mhlekude B, et al. Among authors: thiel v. PLoS Pathog. 2023 Sep 25;19(9):e1011657. doi: 10.1371/journal.ppat.1011657. eCollection 2023 Sep. PLoS Pathog. 2023. PMID: 37747932 Free PMC article.
320 results