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Umbilical cord blood T cells can be isolated and enriched by CD62L selection for use in 'off the shelf' chimeric antigen receptor T-cell therapies to widen transplant options.
Georgiadis C, Nickolay L, Syed F, Zhan H, Gkazi SA, Etuk A, Abramowski-Mock U, Preece R, Cuber P, Adams S, Ottaviano G, Qasim W. Georgiadis C, et al. Among authors: adams s. Haematologica. 2024 Dec 1;109(12):3941-3951. doi: 10.3324/haematol.2024.285101. Haematologica. 2024. PMID: 38988258 Free PMC article.
Omission of in vivo T-cell depletion promotes rapid expansion of naïve CD4+ cord blood lymphocytes and restores adaptive immunity within 2 months after unrelated cord blood transplant.
Chiesa R, Gilmour K, Qasim W, Adams S, Worth AJ, Zhan H, Montiel-Equihua CA, Derniame S, Cale C, Rao K, Hiwarkar P, Hough R, Saudemont A, Fahrenkrog CS, Goulden N, Amrolia PJ, Veys P. Chiesa R, et al. Among authors: adams s. Br J Haematol. 2012 Mar;156(5):656-66. doi: 10.1111/j.1365-2141.2011.08994.x. Epub 2012 Jan 9. Br J Haematol. 2012. PMID: 22224700 Free article.
Host natural killer immunity is a key indicator of permissiveness for donor cell engraftment in patients with severe combined immunodeficiency.
Hassan A, Lee P, Maggina P, Xu JH, Moreira D, Slatter M, Nademi Z, Worth A, Adams S, Jones A, Cale C, Allwood Z, Rao K, Chiesa R, Amrolia P, Gaspar H, Davies EG, Veys P, Gennery A, Qasim W. Hassan A, et al. Among authors: adams s. J Allergy Clin Immunol. 2014 Jun;133(6):1660-6. doi: 10.1016/j.jaci.2014.02.042. Epub 2014 May 1. J Allergy Clin Immunol. 2014. PMID: 24794685 Free PMC article.
Effect of stem cell source on long-term chimerism and event-free survival in children with primary immunodeficiency disorders after fludarabine and melphalan conditioning regimen.
Rao K, Adams S, Qasim W, Allwood Z, Worth A, Silva J, Lucchini G, Chiesa R, Veys P, Amrolia P. Rao K, et al. Among authors: adams s. J Allergy Clin Immunol. 2016 Oct;138(4):1152-1160. doi: 10.1016/j.jaci.2016.01.053. Epub 2016 Apr 20. J Allergy Clin Immunol. 2016. PMID: 27241891
Mutations in linker for activation of T cells (LAT) lead to a novel form of severe combined immunodeficiency.
Bacchelli C, Moretti FA, Carmo M, Adams S, Stanescu HC, Pearce K, Madkaikar M, Gilmour KC, Nicholas AK, Woods CG, Kleta R, Beales PL, Qasim W, Gaspar HB. Bacchelli C, et al. Among authors: adams s. J Allergy Clin Immunol. 2017 Feb;139(2):634-642.e5. doi: 10.1016/j.jaci.2016.05.036. Epub 2016 Jul 15. J Allergy Clin Immunol. 2017. PMID: 27522155 Free article.
Molecular remission of infant B-ALL after infusion of universal TALEN gene-edited CAR T cells.
Qasim W, Zhan H, Samarasinghe S, Adams S, Amrolia P, Stafford S, Butler K, Rivat C, Wright G, Somana K, Ghorashian S, Pinner D, Ahsan G, Gilmour K, Lucchini G, Inglott S, Mifsud W, Chiesa R, Peggs KS, Chan L, Farzeneh F, Thrasher AJ, Vora A, Pule M, Veys P. Qasim W, et al. Among authors: adams s. Sci Transl Med. 2017 Jan 25;9(374):eaaj2013. doi: 10.1126/scitranslmed.aaj2013. Sci Transl Med. 2017. PMID: 28123068
One hundred percent survival after transplantation of 34 patients with Wiskott-Aldrich syndrome over 20 years.
Elfeky RA, Furtado-Silva JM, Chiesa R, Rao K, Amrolia P, Lucchini G, Gilmour K, Adams S, Bibi S, Worth A, Thrasher AJ, Qasim W, Veys P. Elfeky RA, et al. Among authors: adams s. J Allergy Clin Immunol. 2018 Nov;142(5):1654-1656.e7. doi: 10.1016/j.jaci.2018.06.042. Epub 2018 Jul 25. J Allergy Clin Immunol. 2018. PMID: 30055182 No abstract available.
New graft manipulation strategies improve the outcome of mismatched stem cell transplantation in children with primary immunodeficiencies.
Elfeky R, Shah RM, Unni MNM, Ottaviano G, Rao K, Chiesa R, Amrolia P, Worth A, Flood T, Abinun M, Hambleton S, Cant AJ, Gilmour K, Adams S, Ahsan G, Barge D, Gennery AR, Qasim W, Slatter M, Veys P. Elfeky R, et al. Among authors: adams s. J Allergy Clin Immunol. 2019 Jul;144(1):280-293. doi: 10.1016/j.jaci.2019.01.030. Epub 2019 Feb 4. J Allergy Clin Immunol. 2019. PMID: 30731121
3,839 results