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Page 1
Itaconate is a metabolic regulator of bone formation in homeostasis and arthritis.
Kieler M, Prammer LS, Heller G, Hofmann M, Sperger S, Hanetseder D, Niederreiter B, Komljenovic A, Klavins K, Köcher T, Brunner JS, Stanic I, Oberbichler L, Korosec A, Vogel A, Kerndl M, Hromadová D, Musiejovsky L, Hajto A, Dobrijevic A, Piwonka T, Haschemi A, Miller A, Georgel P, Marolt Presen D, Grillari J, Hayer S, Auger JP, Krönke G, Sharif O, Aletaha D, Schabbauer G, Blüml S. Kieler M, et al. Ann Rheum Dis. 2024 Oct 21;83(11):1465-1479. doi: 10.1136/ard-2023-224898. Ann Rheum Dis. 2024. PMID: 38986577 Free PMC article.
Bona fide dendritic cells are pivotal precursors for osteoclasts.
Puchner A, Simader E, Saferding V, Hofmann M, Kieler M, Brunner J, Pfeifle R, Niederreiter B, Krönke G, Schabbauer G, Georgel P, Diehl G, Steiner G, Hayer S, Redlich K, Smolen JS, Aletaha D, Blüml S. Puchner A, et al. Among authors: kieler m. Ann Rheum Dis. 2024 Mar 12;83(4):518-528. doi: 10.1136/ard-2022-223817. Ann Rheum Dis. 2024. PMID: 38071515
Environmental arginine controls multinuclear giant cell metabolism and formation.
Brunner JS, Vulliard L, Hofmann M, Kieler M, Lercher A, Vogel A, Russier M, Brüggenthies JB, Kerndl M, Saferding V, Niederreiter B, Junza A, Frauenstein A, Scholtysek C, Mikami Y, Klavins K, Krönke G, Bergthaler A, O'Shea JJ, Weichhart T, Meissner F, Smolen JS, Cheng P, Yanes O, Menche J, Murray PJ, Sharif O, Blüml S, Schabbauer G. Brunner JS, et al. Among authors: kieler m. Nat Commun. 2020 Jan 22;11(1):431. doi: 10.1038/s41467-020-14285-1. Nat Commun. 2020. PMID: 31969567 Free PMC article.
The PI3K pathway preserves metabolic health through MARCO-dependent lipid uptake by adipose tissue macrophages.
Brunner JS, Vogel A, Lercher A, Caldera M, Korosec A, Pühringer M, Hofmann M, Hajto A, Kieler M, Garrido LQ, Kerndl M, Kuttke M, Mesteri I, Górna MW, Kulik M, Dominiak PM, Brandon AE, Estevez E, Egan CL, Gruber F, Schweiger M, Menche J, Bergthaler A, Weichhart T, Klavins K, Febbraio MA, Sharif O, Schabbauer G. Brunner JS, et al. Among authors: kieler m. Nat Metab. 2020 Dec;2(12):1427-1442. doi: 10.1038/s42255-020-00311-5. Epub 2020 Nov 16. Nat Metab. 2020. PMID: 33199895
JAK1 signaling in dendritic cells promotes peripheral tolerance in autoimmunity through PD-L1-mediated regulatory T cell induction.
Vogel A, Martin K, Soukup K, Halfmann A, Kerndl M, Brunner JS, Hofmann M, Oberbichler L, Korosec A, Kuttke M, Datler H, Kieler M, Musiejovsky L, Dohnal A, Sharif O, Schabbauer G. Vogel A, et al. Among authors: kieler m. Cell Rep. 2022 Feb 22;38(8):110420. doi: 10.1016/j.celrep.2022.110420. Cell Rep. 2022. PMID: 35196494 Free article.
PI3K Signaling in Dendritic Cells Aggravates DSS-Induced Colitis.
Kuttke M, Hromadová D, Yildirim C, Brunner JS, Vogel A, Paar H, Peters S, Weber M, Hofmann M, Kerndl M, Kieler M, Datler H, Musiejovsky L, Salzmann M, Lang M, Soukup K, Halfmann A, Sharif O, Schabbauer G. Kuttke M, et al. Among authors: kieler m. Front Immunol. 2022 Apr 19;13:695576. doi: 10.3389/fimmu.2022.695576. eCollection 2022. Front Immunol. 2022. PMID: 35514976 Free PMC article.
Amino Acids Fueling Fibroblast-Like Synoviocyte Activation and Arthritis By Regulating Chemokine Expression and Leukocyte Migration.
Karonitsch T, Saferding V, Kieler M, von Dalwigk K, Tosevska A, Heller G, Dellinger M, Niederreiter B, Kartnig F, Steiner CW, Georgel P, Kiener HP, Smolen JS, Korb-Pap A, Bonelli M, Aletaha D, Blüml S. Karonitsch T, et al. Among authors: kieler m. Arthritis Rheumatol. 2024 Apr;76(4):531-540. doi: 10.1002/art.42759. Epub 2024 Jan 17. Arthritis Rheumatol. 2024. PMID: 37984422
Metabolic rewiring promotes anti-inflammatory effects of glucocorticoids.
Auger JP, Zimmermann M, Faas M, Stifel U, Chambers D, Krishnacoumar B, Taudte RV, Grund C, Erdmann G, Scholtysek C, Uderhardt S, Ben Brahim O, Pascual Maté M, Stoll C, Böttcher M, Palumbo-Zerr K, Mangan MSJ, Dzamukova M, Kieler M, Hofmann M, Blüml S, Schabbauer G, Mougiakakos D, Sonnewald U, Hartmann F, Simon D, Kleyer A, Grüneboom A, Finotto S, Latz E, Hofmann J, Schett G, Tuckermann J, Krönke G. Auger JP, et al. Among authors: kieler m. Nature. 2024 May;629(8010):184-192. doi: 10.1038/s41586-024-07282-7. Epub 2024 Apr 10. Nature. 2024. PMID: 38600378
42 results