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Monoallelic de novo AJAP1 loss-of-function variants disrupt trans-synaptic control of neurotransmitter release.
Früh S, Boudkkazi S, Koppensteiner P, Sereikaite V, Chen LY, Fernandez-Fernandez D, Rem PD, Ulrich D, Schwenk J, Chen Z, Le Monnier E, Fritzius T, Innocenti SM, Besseyrias V, Trovò L, Stawarski M, Argilli E, Sherr EH, van Bon B, Kamsteeg EJ, Iascone M, Pilotta A, Cutrì MR, Azamian MS, Hernández-García A, Lalani SR, Rosenfeld JA, Zhao X, Vogel TP, Ona H, Scott DA, Scheiffele P, Strømgaard K, Tafti M, Gassmann M, Fakler B, Shigemoto R, Bettler B. Früh S, et al. Among authors: shigemoto r. Sci Adv. 2024 Jul 12;10(28):eadk5462. doi: 10.1126/sciadv.adk5462. Epub 2024 Jul 10. Sci Adv. 2024. PMID: 38985877 Free PMC article.
Differential compartmentalization and distinct functions of GABAB receptor variants.
Vigot R, Barbieri S, Bräuner-Osborne H, Turecek R, Shigemoto R, Zhang YP, Luján R, Jacobson LH, Biermann B, Fritschy JM, Vacher CM, Müller M, Sansig G, Guetg N, Cryan JF, Kaupmann K, Gassmann M, Oertner TG, Bettler B. Vigot R, et al. Among authors: shigemoto r. Neuron. 2006 May 18;50(4):589-601. doi: 10.1016/j.neuron.2006.04.014. Neuron. 2006. PMID: 16701209 Free PMC article.
GABAB receptors induce phasic release from medial habenula terminals through activity-dependent recruitment of release-ready vesicles.
Koppensteiner P, Bhandari P, Önal C, Borges-Merjane C, Le Monnier E, Roy U, Nakamura Y, Sadakata T, Sanbo M, Hirabayashi M, Rhee J, Brose N, Jonas P, Shigemoto R. Koppensteiner P, et al. Among authors: shigemoto r. Proc Natl Acad Sci U S A. 2024 Feb 20;121(8):e2301449121. doi: 10.1073/pnas.2301449121. Epub 2024 Feb 12. Proc Natl Acad Sci U S A. 2024. PMID: 38346189 Free PMC article.
Reduction in the neuronal surface of post and presynaptic GABAB receptors in the hippocampus in a mouse model of Alzheimer's disease.
Martín-Belmonte A, Aguado C, Alfaro-Ruíz R, Moreno-Martínez AE, de la Ossa L, Martínez-Hernández J, Buisson A, Früh S, Bettler B, Shigemoto R, Fukazawa Y, Luján R. Martín-Belmonte A, et al. Among authors: shigemoto r. Brain Pathol. 2020 May;30(3):554-575. doi: 10.1111/bpa.12802. Epub 2019 Dec 12. Brain Pathol. 2020. PMID: 31729777 Free PMC article.
306 results