Eckford PDW - Search Results

1

Comparison of a novel potentiator of CFTR channel activity to ivacaftor in ameliorating mucostasis caused by cigarette smoke in primary human bronchial airway epithelial cells.

Tanjala AC, Jiang JX, Eckford PDW, Ramjeesingh M, Li C, Huan LJ, Langeveld G, Townsend C, Paone DV, Busch-Petersen J, Pekhletski R, Tang L, Raju V, Rowe SM, Bear CE. Tanjala AC, et al. Among authors: eckford pdw. Respir Res. 2024 Jul 10;25(1):269. doi: 10.1186/s12931-024-02889-w. Respir Res. 2024. PMID: 38982492 Free PMC article.

2

Targeting the regulation of CFTR channels.

Eckford PD, Bear CE. Eckford PD, et al. Biochem J. 2011 Apr 15;435(2):e1-4. doi: 10.1042/BJ20110461. Biochem J. 2011. PMID: 21726198

3

Insights into the mechanisms underlying CFTR channel activity, the molecular basis for cystic fibrosis and strategies for therapy.

Kim Chiaw P, Eckford PD, Bear CE. Kim Chiaw P, et al. Essays Biochem. 2011 Sep 7;50(1):233-48. doi: 10.1042/bse0500233. Essays Biochem. 2011. PMID: 21967060 Review.

4

Cystic fibrosis transmembrane conductance regulator (CFTR) potentiator VX-770 (ivacaftor) opens the defective channel gate of mutant CFTR in a phosphorylation-dependent but ATP-independent manner.

Eckford PD, Li C, Ramjeesingh M, Bear CE. Eckford PD, et al. J Biol Chem. 2012 Oct 26;287(44):36639-49. doi: 10.1074/jbc.M112.393637. Epub 2012 Aug 31. J Biol Chem. 2012. PMID: 22942289 Free PMC article.

5

Functional reconstitution and channel activity measurements of purified wildtype and mutant CFTR protein.

Eckford PD, Li C, Bear CE. Eckford PD, et al. J Vis Exp. 2015 Mar 9;(97):52427. doi: 10.3791/52427. J Vis Exp. 2015. PMID: 25867140 Free PMC article.

6

Rescue of multiple class II CFTR mutations by elexacaftor+tezacaftor+ivacaftor mediated in part by the dual activities of elexacaftor as both corrector and potentiator.

Laselva O, Bartlett C, Gunawardena TNA, Ouyang H, Eckford PDW, Moraes TJ, Bear CE, Gonska T. Laselva O, et al. Among authors: eckford pdw. Eur Respir J. 2021 Jun 17;57(6):2002774. doi: 10.1183/13993003.02774-2020. Print 2021 Jun. Eur Respir J. 2021. PMID: 33303536 Free PMC article.

7

Identification and validation of hits from high throughput screens for CFTR modulators.

Pasyk S, Molinski S, Yu W, Eckford PD, Bear CE. Pasyk S, et al. Curr Pharm Des. 2012;18(5):628-41. doi: 10.2174/138161212799315957. Curr Pharm Des. 2012. PMID: 22229556 Review.

8

Eckford PD, Ramjeesingh M, Molinski S, Pasyk S, Dekkers JF, Li C, Ahmadi S, Ip W, Chung TE, Du K, Yeger H, Beekman J, Gonska T, Bear CE. Eckford PD, et al. Chem Biol. 2014 May 22;21(5):666-78. doi: 10.1016/j.chembiol.2014.02.021. Epub 2014 Apr 10. Chem Biol. 2014. PMID: 24726831

9

Attenuation of Phosphorylation-dependent Activation of Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) by Disease-causing Mutations at the Transmission Interface.

Chin S, Yang D, Miles AJ, Eckford PDW, Molinski S, Wallace BA, Bear CE. Chin S, et al. Among authors: eckford pdw. J Biol Chem. 2017 Feb 3;292(5):1988-1999. doi: 10.1074/jbc.M116.762633. Epub 2016 Dec 21. J Biol Chem. 2017. PMID: 28003367 Free PMC article.

10

Orkambi® and amplifier co-therapy improves function from a rare CFTR mutation in gene-edited cells and patient tissue.

Molinski SV, Ahmadi S, Ip W, Ouyang H, Villella A, Miller JP, Lee PS, Kulleperuma K, Du K, Di Paola M, Eckford PD, Laselva O, Huan LJ, Wellhauser L, Li E, Ray PN, Pomès R, Moraes TJ, Gonska T, Ratjen F, Bear CE. Molinski SV, et al. EMBO Mol Med. 2017 Sep;9(9):1224-1243. doi: 10.15252/emmm.201607137. EMBO Mol Med. 2017. PMID: 28667089 Free PMC article.

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