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Blocking HXA3-mediated neutrophil elastase release during S. pneumoniae lung infection limits pulmonary epithelial barrier disruption and bacteremia.
Xu S, Tan S, Romanos P, Reedy JL, Zhang Y, Mansour MK, Vyas JM, Mecsas J, Mou H, Leong JM. Xu S, et al. Among authors: reedy jl. bioRxiv [Preprint]. 2024 Jun 25:2024.06.25.600637. doi: 10.1101/2024.06.25.600637. bioRxiv. 2024. Update in: mBio. 2024 Sep 11;15(9):e0185624. doi: 10.1128/mbio.01856-24 PMID: 38979170 Free PMC article. Updated. Preprint.
BTK inhibitor-induced defects in human neutrophil effector activity against Aspergillus fumigatus are restored by TNF-α.
Vargas-Blanco DA, Hepworth OW, Basham KJ, Simaku P, Crossen AJ, Timmer KD, Hopke A, Brown Harding H, Vandal SR, Jensen KN, Floyd DJ, Reedy JL, Reardon C, Mansour MK, Ward RA, Irimia D, Abramson JS, Vyas JM. Vargas-Blanco DA, et al. Among authors: reedy jl. JCI Insight. 2024 May 7;9(12):e176162. doi: 10.1172/jci.insight.176162. JCI Insight. 2024. PMID: 38713531 Free PMC article.
Single-cell analysis of human airway epithelium identifies cell type-specific responses to Aspergillus and Coccidioides.
Harding AT, Crossen AJ, Reedy JL, Basham KJ, Hepworth OW, Zhang Y, Shah VS, Harding HB, Surve MV, Simaku P, Kwaku GN, Jensen KN, Otto Y, Ward RA, Thompson GR, Klein BS, Rajagopal J, Sen P, Haber AL, Vyas JM. Harding AT, et al. Among authors: reedy jl. bioRxiv [Preprint]. 2024 Sep 13:2024.09.09.612147. doi: 10.1101/2024.09.09.612147. bioRxiv. 2024. PMID: 39314271 Free PMC article. Preprint.
Translational genetics identifies a phosphorylation switch in CARD9 required for innate inflammatory responses.
Brandt M, Cao Z, Krishna C, Reedy JL, Gu X, Dutko RA, Oliver BA, Tusi BK, Park J, Richey L, Segerstolpe Å, Litwiler S, Creasey EA, Carey KL, Vyas JM, Graham DB, Xavier RJ. Brandt M, et al. Among authors: reedy jl. Cell Rep. 2024 Mar 26;43(3):113944. doi: 10.1016/j.celrep.2024.113944. Epub 2024 Mar 13. Cell Rep. 2024. PMID: 38489265 Free PMC article.
Candida albicans extracellular vesicles trigger type I IFN signalling via cGAS and STING.
Brown Harding H, Kwaku GN, Reardon CM, Khan NS, Zamith-Miranda D, Zarnowski R, Tam JM, Bohaen CK, Richey L, Mosallanejad K, Crossen AJ, Reedy JL, Ward RA, Vargas-Blanco DA, Basham KJ, Bhattacharyya RP, Nett JE, Mansour MK, van de Veerdonk FL, Kumar V, Kagan JC, Andes DR, Nosanchuk JD, Vyas JM. Brown Harding H, et al. Among authors: reedy jl. Nat Microbiol. 2024 Jan;9(1):95-107. doi: 10.1038/s41564-023-01546-0. Epub 2024 Jan 2. Nat Microbiol. 2024. PMID: 38168615 Free PMC article.
45 results