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Endothelial, pericyte and tumor cell expression in glioblastoma identifies fibroblast activation protein (FAP) as an excellent target for immunotherapy.
Ebert LM, Yu W, Gargett T, Toubia J, Kollis PM, Tea MN, Ebert BW, Bardy C, van den Hurk M, Bonder CS, Manavis J, Ensbey KS, Oksdath Mansilla M, Scheer KG, Perrin SL, Ormsby RJ, Poonnoose S, Koszyca B, Pitson SM, Day BW, Gomez GA, Brown MP. Ebert LM, et al. Among authors: yu w. Clin Transl Immunology. 2020 Oct 14;9(10):e1191. doi: 10.1002/cti2.1191. eCollection 2020. Clin Transl Immunology. 2020. PMID: 33082953 Free PMC article.
GD2-targeting CAR-T cells enhanced by transgenic IL-15 expression are an effective and clinically feasible therapy for glioblastoma.
Gargett T, Ebert LM, Truong NTH, Kollis PM, Sedivakova K, Yu W, Yeo ECF, Wittwer NL, Gliddon BL, Tea MN, Ormsby R, Poonnoose S, Nowicki J, Vittorio O, Ziegler DS, Pitson SM, Brown MP. Gargett T, et al. Among authors: yu w. J Immunother Cancer. 2022 Sep;10(9):e005187. doi: 10.1136/jitc-2022-005187. J Immunother Cancer. 2022. PMID: 36167468 Free PMC article.
Safety and biological outcomes following a phase 1 trial of GD2-specific CAR-T cells in patients with GD2-positive metastatic melanoma and other solid cancers.
Gargett T, Truong NTH, Gardam B, Yu W, Ebert LM, Johnson A, Yeo ECF, Wittwer NL, Tapia Rico G, Logan J, Sivaloganathan P, Collis M, Ruszkiewicz A, Brown MP. Gargett T, et al. Among authors: yu w. J Immunother Cancer. 2024 May 15;12(5):e008659. doi: 10.1136/jitc-2023-008659. J Immunother Cancer. 2024. PMID: 38754916 Free PMC article. Clinical Trial.
Demethylating therapy increases anti-CD123 CAR T cell cytotoxicity against acute myeloid leukemia.
El Khawanky N, Hughes A, Yu W, Myburgh R, Matschulla T, Taromi S, Aumann K, Clarson J, Vinnakota JM, Shoumariyeh K, Miething C, Lopez AF, Brown MP, Duyster J, Hein L, Manz MG, Hughes TP, White DL, Yong ASM, Zeiser R. El Khawanky N, et al. Among authors: yu w. Nat Commun. 2021 Nov 8;12(1):6436. doi: 10.1038/s41467-021-26683-0. Nat Commun. 2021. PMID: 34750374 Free PMC article.
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