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IL-27-engineered CAR.19-NK-92 cells exhibit enhanced therapeutic efficacy.
Biggi AFB, Silvestre RN, Tirapelle MC, de Azevedo JTC, García HDM, Henrique Dos Santos M, de Lima SCG, de Souza LEB, Covas DT, Malmegrim KCR, Figueiredo ML, Picanço-Castro V. Biggi AFB, et al. Among authors: tirapelle mc. Cytotherapy. 2024 Nov;26(11):1320-1330. doi: 10.1016/j.jcyt.2024.06.001. Epub 2024 Jun 6. Cytotherapy. 2024. PMID: 38970613 Free article.
Engineering NK-CAR.19 cells with the IL-15/IL-15Rα complex improved proliferation and anti-tumor effect in vivo.
Silvestre RN, Eitler J, de Azevedo JTC, Tirapelle MC, Fantacini DMC, de Souza LEB, Swiech K, Covas DT, Calado RT, Montero PO, Malmegrim KCR, Figueiredo ML, Tonn T, Picanço-Castro V. Silvestre RN, et al. Among authors: tirapelle mc. Front Immunol. 2023 Sep 25;14:1226518. doi: 10.3389/fimmu.2023.1226518. eCollection 2023. Front Immunol. 2023. PMID: 37818365 Free PMC article.