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Page 1
Effects of intermittent senolytic therapy on bone metabolism in postmenopausal women: a phase 2 randomized controlled trial.
Farr JN, Atkinson EJ, Achenbach SJ, Volkman TL, Tweed AJ, Vos SJ, Ruan M, Sfeir J, Drake MT, Saul D, Doolittle ML, Bancos I, Yu K, Tchkonia T, LeBrasseur NK, Kirkland JL, Monroe DG, Khosla S. Farr JN, et al. Among authors: doolittle ml. Nat Med. 2024 Sep;30(9):2605-2612. doi: 10.1038/s41591-024-03096-2. Epub 2024 Jul 2. Nat Med. 2024. PMID: 38956196 Clinical Trial.
A new gene set identifies senescent cells and predicts senescence-associated pathways across tissues.
Saul D, Kosinsky RL, Atkinson EJ, Doolittle ML, Zhang X, LeBrasseur NK, Pignolo RJ, Robbins PD, Niedernhofer LJ, Ikeno Y, Jurk D, Passos JF, Hickson LJ, Xue A, Monroe DG, Tchkonia T, Kirkland JL, Farr JN, Khosla S. Saul D, et al. Among authors: doolittle ml. Nat Commun. 2022 Aug 16;13(1):4827. doi: 10.1038/s41467-022-32552-1. Nat Commun. 2022. PMID: 35974106 Free PMC article.
Osteocyte Cellular Senescence.
Farr JN, Kaur J, Doolittle ML, Khosla S. Farr JN, et al. Among authors: doolittle ml. Curr Osteoporos Rep. 2020 Oct;18(5):559-567. doi: 10.1007/s11914-020-00619-x. Curr Osteoporos Rep. 2020. PMID: 32794138 Free PMC article. Review.
Skeletal Effects of Inducible ERα Deletion in Osteocytes in Adult Mice.
Doolittle ML, Saul D, Kaur J, Rowsey JL, Eckhardt B, Vos S, Grain S, Kroupova K, Ruan M, Weivoda M, Oursler MJ, Farr JN, Monroe DG, Khosla S. Doolittle ML, et al. J Bone Miner Res. 2022 Sep;37(9):1750-1760. doi: 10.1002/jbmr.4644. Epub 2022 Jul 22. J Bone Miner Res. 2022. PMID: 35789113 Free PMC article.
Multiparametric senescent cell phenotyping reveals CD24 osteolineage cells as targets of senolytic therapy in the aged murine skeleton.
Doolittle ML, Saul D, Kaur J, Rowsey JL, Vos SJ, Pavelko KD, Farr JN, Monroe DG, Khosla S. Doolittle ML, et al. bioRxiv [Preprint]. 2023 Jan 13:2023.01.12.523760. doi: 10.1101/2023.01.12.523760. bioRxiv. 2023. Update in: Nat Commun. 2023 Jul 31;14(1):4587. doi: 10.1038/s41467-023-40393-9 PMID: 36711531 Free PMC article. Updated. Preprint.
26 results