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Page 1
HIV-1 subtype A1, D, and recombinant proviral genome landscapes during long-term suppressive therapy.
Lee GQ, Khadka P, Gowanlock SN, Copertino DC Jr, Duncan MC, Omondi FH, Kinloch NN, Kasule J, Kityamuweesi T, Buule P, Jamiru S, Tomusange S, Anok A, Chen Z, Jones RB, Galiwango RM, Reynolds SJ, Quinn TC, Brumme ZL, Redd AD, Prodger JL. Lee GQ, et al. Among authors: brumme zl. Nat Commun. 2024 Jul 2;15(1):5480. doi: 10.1038/s41467-024-48985-9. Nat Commun. 2024. PMID: 38956017 Free PMC article.
A simple phylogenetic approach to analyze hypermutated HIV proviruses reveals insights into their dynamics and persistence during antiretroviral therapy.
Shahid A, Jones BR, Duncan MC, MacLennan S, Dapp MJ, Kuniholm MH, Aouizerat B, Archin NM, Gange S, Ofotokun I, Fischl MA, Kassaye S, Goldstein H, Anastos K, Joy JB, Brumme ZL. Shahid A, et al. Among authors: brumme zl. Res Sq [Preprint]. 2024 Jun 13:rs.3.rs-4549934. doi: 10.21203/rs.3.rs-4549934/v1. Res Sq. 2024. PMID: 38947061 Free PMC article. Preprint.
No detectable differences in Nef-mediated downregulation of HLA-I and CD4 molecules among HIV-1 group M lineages circulating in Cameroon, where the pandemic originated.
Sonela N, Mann J, Godwe C, Goni OH, Tchakoute M, Nkoue N, de Oliveira T, Brockman MA, Brumme ZL, Ndung'u T, Tongo M. Sonela N, et al. Among authors: brumme zl. Front Virol. 2024 May 29;4:fviro.2024.1379217. doi: 10.3389/fviro.2024.1379217. Front Virol. 2024. PMID: 38883214 Free PMC article.
Correlates of Breakthrough SARS-CoV-2 Infections in People with HIV: Results from the CIHR CTN 328 Study.
Costiniuk CT, Lee T, Singer J, Galipeau Y, Arnold C, Langlois MA, Needham J, Jenabian MA, Burchell AN, Samji H, Chambers C, Walmsley S, Ostrowski M, Kovacs C, Tan DHS, Harris M, Hull M, Brumme ZL, Lapointe HR, Brockman MA, Margolese S, Mandarino E, Samarani S, Lebouché B, Angel JB, Routy JP, Cooper CL, Anis AH; COVAXHIV Study Group. Costiniuk CT, et al. Among authors: brumme zl. Vaccines (Basel). 2024 Apr 23;12(5):447. doi: 10.3390/vaccines12050447. Vaccines (Basel). 2024. PMID: 38793698 Free PMC article.
T-Cell Responses to COVID-19 Vaccines and Breakthrough Infection in People Living with HIV Receiving Antiretroviral Therapy.
Datwani S, Kalikawe R, Waterworth R, Mwimanzi FM, Liang R, Sang Y, Lapointe HR, Cheung PK, Omondi FH, Duncan MC, Barad E, Speckmaier S, Moran-Garcia N, DeMarco ML, Hedgcock M, Costiniuk CT, Hull M, Harris M, Romney MG, Montaner JSG, Brumme ZL, Brockman MA. Datwani S, et al. Among authors: brumme zl. Viruses. 2024 Apr 24;16(5):661. doi: 10.3390/v16050661. Viruses. 2024. PMID: 38793543 Free PMC article.
Effects of COVID-19 mRNA vaccination on HIV viremia and reservoir size.
Duncan MC, Omondi FH, Kinloch NN, Lapointe HR, Speckmaier S, Moran-Garcia N, Lawson T, DeMarco ML, Simons J, Holmes DT, Lowe CF, Bacani N, Sereda P, Barrios R, Harris M, Romney MG, Montaner JSG, Brumme CJ, Brockman MA, Brumme ZL. Duncan MC, et al. Among authors: brumme zl. AIDS. 2024 Jul 1;38(8):1120-1130. doi: 10.1097/QAD.0000000000003841. Epub 2024 Jan 22. AIDS. 2024. PMID: 38224350 Free PMC article.
The replication-competent HIV reservoir is a genetically restricted, younger subset of the overall pool of HIV proviruses persisting during therapy, which is highly genetically stable over time.
Shahid A, MacLennan S, Jones BR, Sudderuddin H, Dang Z, Cobarrubias K, Duncan MC, Kinloch NN, Dapp MJ, Archin NM, Fischl MA, Ofotokun I, Adimora A, Gange S, Aouizerat B, Kuniholm MH, Kassaye S, Mullins JI, Goldstein H, Joy JB, Anastos K, Brumme ZL; MACS/WIHS combined cohort study (MWCSS). Shahid A, et al. Among authors: brumme zl. J Virol. 2024 Feb 20;98(2):e0165523. doi: 10.1128/jvi.01655-23. Epub 2024 Jan 12. J Virol. 2024. PMID: 38214547 Free PMC article.
Dynamics of T-cell Responses Following COVID-19 mRNA Vaccination and Breakthrough Infection in Older Adults.
Datwani S, Kalikawe R, Mwimanzi F, Speckmaier S, Liang R, Sang Y, Waterworth R, Yaseen F, Lapointe HR, Barad E, DeMarco ML, Holmes DT, Simons J, Montaner JSG, Romney MG, Brumme ZL, Brockman MA. Datwani S, et al. Among authors: brumme zl. Pathog Immun. 2023 Nov 17;8(1):117-135. doi: 10.20411/pai.v8i1.613. eCollection 2023. Pathog Immun. 2023. PMID: 38035132 Free PMC article.
HIV reservoirs are dominated by genetically younger and clonally enriched proviruses.
Kinloch NN, Shahid A, Dong W, Kirkby D, Jones BR, Beelen CJ, MacMillan D, Lee GQ, Mota TM, Sudderuddin H, Barad E, Harris M, Brumme CJ, Jones RB, Brockman MA, Joy JB, Brumme ZL. Kinloch NN, et al. Among authors: brumme zl. mBio. 2023 Dec 19;14(6):e0241723. doi: 10.1128/mbio.02417-23. Epub 2023 Nov 16. mBio. 2023. PMID: 37971267 Free PMC article.
211 results