Ciulli A - Search Results

1

Stereochemical inversion at a 1,4-cyclohexyl PROTAC linker fine-tunes conformation and binding affinity.

Pierri M, Liu X, Kroupova A, Rutter Z, Hallatt AJ, Ciulli A. Pierri M, et al. Among authors: ciulli a. Bioorg Med Chem Lett. 2024 Sep 15;110:129861. doi: 10.1016/j.bmcl.2024.129861. Epub 2024 Jun 26. Bioorg Med Chem Lett. 2024. PMID: 38942127 Free article.

2

Application of fragment screening and merging to the discovery of inhibitors of the Mycobacterium tuberculosis cytochrome P450 CYP121.

Hudson SA, McLean KJ, Surade S, Yang YQ, Leys D, Ciulli A, Munro AW, Abell C. Hudson SA, et al. Among authors: ciulli a. Angew Chem Int Ed Engl. 2012 Sep 10;51(37):9311-6. doi: 10.1002/anie.201202544. Epub 2012 Aug 13. Angew Chem Int Ed Engl. 2012. PMID: 22890978 No abstract available.

3

Targeting the von Hippel-Lindau E3 ubiquitin ligase using small molecules to disrupt the VHL/HIF-1α interaction.

Buckley DL, Van Molle I, Gareiss PC, Tae HS, Michel J, Noblin DJ, Jorgensen WL, Ciulli A, Crews CM. Buckley DL, et al. Among authors: ciulli a. J Am Chem Soc. 2012 Mar 14;134(10):4465-8. doi: 10.1021/ja209924v. Epub 2012 Feb 27. J Am Chem Soc. 2012. PMID: 22369643 Free PMC article.

4

Small-molecule inhibitors of the interaction between the E3 ligase VHL and HIF1α.

Buckley DL, Gustafson JL, Van Molle I, Roth AG, Tae HS, Gareiss PC, Jorgensen WL, Ciulli A, Crews CM. Buckley DL, et al. Among authors: ciulli a. Angew Chem Int Ed Engl. 2012 Nov 12;51(46):11463-7. doi: 10.1002/anie.201206231. Epub 2012 Oct 12. Angew Chem Int Ed Engl. 2012. PMID: 23065727 Free PMC article.

5

The 2^nd Alpine Winter Conference on Medicinal and Synthetic Chemistry.

Ciulli A, Hamann L, Jahnke W, Kalgutkar AS, Magauer T, Ritter T, Steadman V, Williams SD, Winter G, Hoegenauer K, Krawinkler KH, Stepan AF. Ciulli A, et al. ChemMedChem. 2021 Aug 5;16(15):2417-2423. doi: 10.1002/cmdc.202100372. Epub 2021 Jun 10. ChemMedChem. 2021. PMID: 34114371

6

The biochemical properties of the two Arabidopsis thaliana isochorismate synthases.

Macaulay KM, Heath GA, Ciulli A, Murphy AM, Abell C, Carr JP, Smith AG. Macaulay KM, et al. Among authors: ciulli a. Biochem J. 2017 Apr 28;474(10):1579-1590. doi: 10.1042/BCJ20161069. Biochem J. 2017. PMID: 28356402 Free PMC article.

7

Optimization of the interligand Overhauser effect for fragment linking: application to inhibitor discovery against Mycobacterium tuberculosis pantothenate synthetase.

Sledz P, Silvestre HL, Hung AW, Ciulli A, Blundell TL, Abell C. Sledz P, et al. Among authors: ciulli a. J Am Chem Soc. 2010 Apr 7;132(13):4544-5. doi: 10.1021/ja100595u. J Am Chem Soc. 2010. PMID: 20232910 Free PMC article.

8

Application of fragment growing and fragment linking to the discovery of inhibitors of Mycobacterium tuberculosis pantothenate synthetase.

Hung AW, Silvestre HL, Wen S, Ciulli A, Blundell TL, Abell C. Hung AW, et al. Among authors: ciulli a. Angew Chem Int Ed Engl. 2009;48(45):8452-6. doi: 10.1002/anie.200903821. Angew Chem Int Ed Engl. 2009. PMID: 19780086 No abstract available.

9

Binding hotspots of BAZ2B bromodomain: Histone interaction revealed by solution NMR driven docking.

Ferguson FM, Dias DM, Rodrigues JP, Wienk H, Boelens R, Bonvin AM, Abell C, Ciulli A. Ferguson FM, et al. Among authors: ciulli a. Biochemistry. 2014 Oct 28;53(42):6706-16. doi: 10.1021/bi500909d. Epub 2014 Oct 15. Biochemistry. 2014. PMID: 25266743 Free PMC article.

10

Biophysical characterization of laforin-carbohydrate interaction.

Dias DM, Furtado J, Wasielewski E, Cruz R, Costello B, Cole L, Faria TQ, Baaske P, Brito RM, Ciulli A, Simões I, Macedo-Ribeiro S, Faro C, Geraldes CF, Castanheira P. Dias DM, et al. Among authors: ciulli a. Biochem J. 2016 Feb 1;473(3):335-45. doi: 10.1042/BJ20141555. Epub 2015 Nov 17. Biochem J. 2016. PMID: 26578817

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