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Page 1
Transplantation of a genetically modified porcine heart into a live human.
Griffith BP, Grazioli A, Singh AK, Tully A, Galindo J, Saharia KK, Shah A, Strauss ER, Odonkor PN, Williams B, Silverman HJ, Burke A, Drachenberg CB, Wells CL, Dickfeld T, Hong SN, Hicks AJ 3rd, Ananthram M, Gupta A, Christenson RH, Tamburro L, Zhang T, Hershfeld A, Lewis B, Feller ED, Kuravi K, Sorrells L, Morgand E, Mezine F, Goutaudier V, Rothblatt M, Lau CL, Taylor B, Perrin S, Loupy A, Ayares D, Mohiuddin MM. Griffith BP, et al. Among authors: sorrells l. Nat Med. 2025 Jan 8. doi: 10.1038/s41591-024-03429-1. Online ahead of print. Nat Med. 2025. PMID: 39779924
Extended survival of 9- and 10-gene-edited pig heart xenografts with ischemia minimization and CD154 costimulation blockade-based immunosuppression.
Chaban R, Ileka I, McGrath G, Kinoshita K, Habibabady Z, Ma M, Diaz V, Maenaka A, Calhoun A, Dufault M, Rosales I, Laguerre CM, Sanatkar SA, Burdorf L, Ayares DL, Eyestone W, Sardana P, Kuravi K, Sorrells L, Lederman S, Lucas CG, Prather RS, Wells KD, Whitworth KM, Cooper DKC, Pierson RN 3rd. Chaban R, et al. Among authors: sorrells l. J Heart Lung Transplant. 2024 Dec;43(12):1932-1944. doi: 10.1016/j.healun.2024.07.022. Epub 2024 Aug 7. J Heart Lung Transplant. 2024. PMID: 39097214
Consistent survival in consecutive cases of life-supporting porcine kidney xenotransplantation using 10GE source pigs.
Eisenson D, Hisadome Y, Santillan M, Iwase H, Chen W, Shimizu A, Schulick A, Gu D, Akbar A, Zhou A, Koenig K, Kuravi K, Rahman F, Sorrells L, Burdorf L, DeSmet K, Warren D, Peterson L, Lorber M, Ayares D, Cameron A, Yamada K. Eisenson D, et al. Among authors: sorrells l. Nat Commun. 2024 Apr 18;15(1):3361. doi: 10.1038/s41467-024-47679-6. Nat Commun. 2024. PMID: 38637524 Free PMC article.
Pig-to-human heart xenotransplantation in two recently deceased human recipients.
Moazami N, Stern JM, Khalil K, Kim JI, Narula N, Mangiola M, Weldon EP, Kagermazova L, James L, Lawson N, Piper GL, Sommer PM, Reyentovich A, Bamira D, Saraon T, Kadosh BS, DiVita M, Goldberg RI, Hussain ST, Chan J, Ngai J, Jan T, Ali NM, Tatapudi VS, Segev DL, Bisen S, Jaffe IS, Piegari B, Kowalski H, Kokkinaki M, Monahan J, Sorrells L, Burdorf L, Boeke JD, Pass H, Goparaju C, Keating B, Ayares D, Lorber M, Griesemer A, Mehta SA, Smith DE, Montgomery RA. Moazami N, et al. Among authors: sorrells l. Nat Med. 2023 Aug;29(8):1989-1997. doi: 10.1038/s41591-023-02471-9. Epub 2023 Jul 24. Nat Med. 2023. PMID: 37488288
Graft dysfunction in compassionate use of genetically engineered pig-to-human cardiac xenotransplantation: a case report.
Mohiuddin MM, Singh AK, Scobie L, Goerlich CE, Grazioli A, Saharia K, Crossan C, Burke A, Drachenberg C, Oguz C, Zhang T, Lewis B, Hershfeld A, Sentz F, Tatarov I, Mudd S, Braileanu G, Rice K, Paolini JF, Bondensgaard K, Vaught T, Kuravi K, Sorrells L, Dandro A, Ayares D, Lau C, Griffith BP. Mohiuddin MM, et al. Among authors: sorrells l. Lancet. 2023 Jul 29;402(10399):397-410. doi: 10.1016/S0140-6736(23)00775-4. Epub 2023 Jun 29. Lancet. 2023. PMID: 37393920 Free PMC article.
Progressive genetic modifications of porcine cardiac xenografts extend survival to 9 months.
Mohiuddin MM, Goerlich CE, Singh AK, Zhang T, Tatarov I, Lewis B, Sentz F, Hershfeld A, Braileanu G, Odonkor P, Strauss E, Williams B, Burke A, Hittman J, Bhutta A, Tabatabai A, Gupta A, Vaught T, Sorrells L, Kuravi K, Dandro A, Eyestone W, Kaczorowski DJ, Ayares D, Griffith BP. Mohiuddin MM, et al. Among authors: sorrells l. Xenotransplantation. 2022 May;29(3):e12744. doi: 10.1111/xen.12744. Epub 2022 Mar 31. Xenotransplantation. 2022. PMID: 35357044 Free PMC article.
Effects of human TFPI and CD47 expression and selectin and integrin inhibition during GalTKO.hCD46 pig lung perfusion with human blood.
Miura S, Habibabady ZA, Pollok F, Connolly M, Pratts S, Dandro A, Sorrells L, Karavi K, Phelps C, Eyestone W, Ayares D, Burdorf L, Azimzadeh A, Pierson RN 3rd. Miura S, et al. Among authors: sorrells l. Xenotransplantation. 2022 Mar;29(2):e12725. doi: 10.1111/xen.12725. Epub 2022 Mar 2. Xenotransplantation. 2022. PMID: 35234315 Free PMC article.
hEPCR.hTBM.hCD47.hHO-1 with donor clodronate and DDAVP treatment improves perfusion and function of GalTKO.hCD46 porcine livers perfused with human blood.
Cimeno A, Kuravi K, Sorrells L, Dandro A, Sendil S, Burdorf L, Parsell DM, Eyestone W, Phelps C, Ayares D, Azimzadeh AM, Pierson RN 3rd, Barth RN, LaMattina JC. Cimeno A, et al. Among authors: sorrells l. Xenotransplantation. 2022 Mar;29(2):e12731. doi: 10.1111/xen.12731. Epub 2022 Feb 15. Xenotransplantation. 2022. PMID: 35166407 Free PMC article.
15 results