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Increased alpha-synuclein and neuroinflammation in the substantia nigra triggered by systemic inflammation are reversed by targeted inhibition of the receptor for advanced glycation end products (RAGE).
Peixoto DO, Bittencourt RR, Gasparotto J, Kessler FGC, Brum PO, Somensi N, Girardi CS, Dos Santos da Silva L, Outeiro TF, Moreira JCF, Gelain DP. Peixoto DO, et al. Among authors: gelain dp. J Neurochem. 2024 Aug;168(8):1587-1607. doi: 10.1111/jnc.15956. Epub 2023 Sep 3. J Neurochem. 2024. PMID: 37661637
The effects of retinol oral supplementation in 6-hydroxydopamine dopaminergic denervation model in Wistar rats.
Kunzler A, Ribeiro CT, Gasparotto J, Petiz LL, da Rosa Silva HT, da Silva JD Jr, Bortolin R, de Souza PO, Barreto F, Espitia-Perez P, Schnorr CE, Somensi N, Moreira JCF, Gelain DP. Kunzler A, et al. Among authors: gelain dp. Neurochem Int. 2019 May;125:25-34. doi: 10.1016/j.neuint.2019.02.002. Epub 2019 Feb 7. Neurochem Int. 2019. PMID: 30739037
Oral administration of carvacrol/β-cyclodextrin complex protects against 6-hydroxydopamine-induced dopaminergic denervation.
Tiefensee Ribeiro C, Gasparotto J, Petiz LL, Brum PO, Peixoto DO, Kunzler A, da Rosa Silva HT, Bortolin RC, Almeida RF, Quintans-Junior LJ, Araújo AA, Moreira JCF, Gelain DP. Tiefensee Ribeiro C, et al. Among authors: gelain dp. Neurochem Int. 2019 Jun;126:27-35. doi: 10.1016/j.neuint.2019.02.021. Epub 2019 Mar 5. Neurochem Int. 2019. PMID: 30849398 Free article.
High fat diet-induced obesity causes a reduction in brain tyrosine hydroxylase levels and non-motor features in rats through metabolic dysfunction, neuroinflammation and oxidative stress.
Bittencourt A, Brum PO, Ribeiro CT, Gasparotto J, Bortolin RC, de Vargas AR, Heimfarth L, de Almeida RF, Moreira JCF, de Oliveira J, Gelain DP. Bittencourt A, et al. Among authors: gelain dp. Nutr Neurosci. 2022 May;25(5):1026-1040. doi: 10.1080/1028415X.2020.1831261. Epub 2020 Oct 20. Nutr Neurosci. 2022. PMID: 33078695
174 results