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Discovery of KT-413, a Targeted Protein Degrader of IRAK4 and IMiD Substrates Targeting MYD88 Mutant Diffuse Large B-Cell Lymphoma.
Weiss MM, Zheng X, Ji N, Browne CM, Campbell V, Chen D, Enerson B, Fei X, Huang X, Klaus CR, Li H, Mayo M, McDonald AA, Paul A, Rong H, Sharma K, Shi Y, Slavin A, Walther DM, Yuan K, Zhang Y, Zhu X, Kelleher J, Walker D, Mainolfi N. Weiss MM, et al. Among authors: yuan k. J Med Chem. 2024 Jul 11;67(13):10548-10566. doi: 10.1021/acs.jmedchem.3c01823. Epub 2024 Jun 26. J Med Chem. 2024. PMID: 38920289
Discovery of KT-474─a Potent, Selective, and Orally Bioavailable IRAK4 Degrader for the Treatment of Autoimmune Diseases.
Zheng X, Ji N, Campbell V, Slavin A, Zhu X, Chen D, Rong H, Enerson B, Mayo M, Sharma K, Browne CM, Klaus CR, Li H, Massa G, McDonald AA, Shi Y, Sintchak M, Skouras S, Walther DM, Yuan K, Zhang Y, Kelleher J, Liu G, Luo X, Mainolfi N, Weiss MM. Zheng X, et al. Among authors: yuan k. J Med Chem. 2024 Oct 24;67(20):18022-18037. doi: 10.1021/acs.jmedchem.4c01305. Epub 2024 Aug 16. J Med Chem. 2024. PMID: 39151120 Free PMC article. Clinical Trial.
Buqi-Tongluo Decoction inhibits osteoclastogenesis and alleviates bone loss in ovariectomized rats by attenuating NFATc1, MAPK, NF-κB signaling.
Li Y, Yuan J, Deng W, Li H, Lin Y, Yang J, Chen K, Qiu H, Wang Z, Kuek V, Wang D, Zhang Z, Mai B, Shao Y, Kang P, Qin Q, Li J, Guo H, Ma Y, Guo D, Mo G, Fang Y, Tan R, Zhan C, Liu T, Gu G, Yuan K, Tang Y, Liang D, Xu L, Xu J, Zhang S. Li Y, et al. Among authors: yuan k. Chin J Nat Med. 2025 Jan;23(1):90-101. doi: 10.1016/S1875-5364(25)60810-7. Chin J Nat Med. 2025. PMID: 39855834
Directional Freeze-Casting Cryogel Loaded with Quaternized Chitosan Modified Gallium Metal-Organic Frameworks to Capture and Eradicate the Resistant Bacteria for Guided Regeneration in Infected Bone Defects.
Liu Y, Yuan K, Lin Y, Yang Y, Kong W, Shan J, Niu H, Kong W, Li F, Yue X, Du Y, Liang Y, Chang H, Yu Z, Wang J, Yang G, Cao L, Huang K, Yang S, Tang T. Liu Y, et al. Among authors: yuan k. Adv Mater. 2025 Jan 23:e2414437. doi: 10.1002/adma.202414437. Online ahead of print. Adv Mater. 2025. PMID: 39846310
2,554 results