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Discovery of KT-413, a Targeted Protein Degrader of IRAK4 and IMiD Substrates Targeting MYD88 Mutant Diffuse Large B-Cell Lymphoma.
Weiss MM, Zheng X, Ji N, Browne CM, Campbell V, Chen D, Enerson B, Fei X, Huang X, Klaus CR, Li H, Mayo M, McDonald AA, Paul A, Rong H, Sharma K, Shi Y, Slavin A, Walther DM, Yuan K, Zhang Y, Zhu X, Kelleher J, Walker D, Mainolfi N. Weiss MM, et al. Among authors: sharma k. J Med Chem. 2024 Jul 11;67(13):10548-10566. doi: 10.1021/acs.jmedchem.3c01823. Epub 2024 Jun 26. J Med Chem. 2024. PMID: 38920289
IRAK4 degrader in hidradenitis suppurativa and atopic dermatitis: a phase 1 trial.
Ackerman L, Acloque G, Bacchelli S, Schwartz H, Feinstein BJ, La Stella P, Alavi A, Gollerkeri A, Davis J, Campbell V, McDonald A, Agarwal S, Karnik R, Shi K, Mishkin A, Culbertson J, Klaus C, Enerson B, Massa V, Kuhn E, Sharma K, Keaney E, Barnes R, Chen D, Zheng X, Rong H, Sabesan V, Ho C, Mainolfi N, Slavin A, Gollob JA. Ackerman L, et al. Among authors: sharma k. Nat Med. 2023 Dec;29(12):3127-3136. doi: 10.1038/s41591-023-02635-7. Epub 2023 Nov 13. Nat Med. 2023. PMID: 37957373 Free PMC article. Clinical Trial.
Discovery of KT-474─a Potent, Selective, and Orally Bioavailable IRAK4 Degrader for the Treatment of Autoimmune Diseases.
Zheng X, Ji N, Campbell V, Slavin A, Zhu X, Chen D, Rong H, Enerson B, Mayo M, Sharma K, Browne CM, Klaus CR, Li H, Massa G, McDonald AA, Shi Y, Sintchak M, Skouras S, Walther DM, Yuan K, Zhang Y, Kelleher J, Liu G, Luo X, Mainolfi N, Weiss MM. Zheng X, et al. Among authors: sharma k. J Med Chem. 2024 Oct 24;67(20):18022-18037. doi: 10.1021/acs.jmedchem.4c01305. Epub 2024 Aug 16. J Med Chem. 2024. PMID: 39151120 Free PMC article. Clinical Trial.
Sacubitril/valsartan versus valsartan initiation in patients naïve to renin-angiotensin system inhibitors: Insights from PARAGLIDE-HF.
Nouhravesh N, Gunn AH, Cyr D, Hernandez AF, Morrow DA, Velazquez EJ, Ward JH, Sarwat S, Sharma K, Williamson KM, Starling RC, Lepage S, Zieroth S, Solomon SD, Mentz RJ. Nouhravesh N, et al. Among authors: sharma k. Eur J Heart Fail. 2025 Jan 10. doi: 10.1002/ejhf.3579. Online ahead of print. Eur J Heart Fail. 2025. PMID: 39792134
Prevalence of traditional cardiovascular risk factors in high-risk Kyrgyzstan population as compared to Indians - An Indo-Kyrgyz cardiometabolic study.
Sharma K, Mohan S, Hossain SA, Shah S, Konat A, Shah K, Mehta S, Tavethia JJ, Sarvaiya JN, Joshi S, Shah K, Patel DR, Patel S. Sharma K, et al. J Family Med Prim Care. 2024 Dec;13(12):5621-5625. doi: 10.4103/jfmpc.jfmpc_712_24. Epub 2024 Dec 9. J Family Med Prim Care. 2024. PMID: 39790788 Free PMC article.
An ODE-based swift and dynamic sewer airflow model.
Shi T, Li J, Ge J, Watts S, Wang Y, Sharma K, Yuan Z. Shi T, et al. Among authors: sharma k. Water Res. 2024 Dec 31;273:123083. doi: 10.1016/j.watres.2024.123083. Online ahead of print. Water Res. 2024. PMID: 39787751
4,922 results