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Orpinolide disrupts a leukemic dependency on cholesterol transport by inhibiting OSBP.
Cigler M, Imrichova H, Frommelt F, Caramelle L, Depta L, Rukavina A, Kagiou C, Hannich JT, Mayor-Ruiz C, Superti-Furga G, Sievers S, Forrester A, Laraia L, Waldmann H, Winter GE. Cigler M, et al. Among authors: waldmann h. Nat Chem Biol. 2024 Jun 21. doi: 10.1038/s41589-024-01614-4. Online ahead of print. Nat Chem Biol. 2024. PMID: 38907113
Analysis of the eukaryotic prenylome by isoprenoid affinity tagging.
Nguyen UT, Guo Z, Delon C, Wu Y, Deraeve C, Fränzel B, Bon RS, Blankenfeldt W, Goody RS, Waldmann H, Wolters D, Alexandrov K. Nguyen UT, et al. Among authors: waldmann h. Nat Chem Biol. 2009 Apr;5(4):227-35. doi: 10.1038/nchembio.149. Epub 2009 Feb 15. Nat Chem Biol. 2009. PMID: 19219049
Small-molecule inhibition of APT1 affects Ras localization and signaling.
Dekker FJ, Rocks O, Vartak N, Menninger S, Hedberg C, Balamurugan R, Wetzel S, Renner S, Gerauer M, Schölermann B, Rusch M, Kramer JW, Rauh D, Coates GW, Brunsveld L, Bastiaens PI, Waldmann H. Dekker FJ, et al. Among authors: waldmann h. Nat Chem Biol. 2010 Jun;6(6):449-56. doi: 10.1038/nchembio.362. Epub 2010 Apr 25. Nat Chem Biol. 2010. PMID: 20418879
Small-molecule phenotypic screening with stem cells.
Ursu A, Schöler HR, Waldmann H. Ursu A, et al. Among authors: waldmann h. Nat Chem Biol. 2017 May 17;13(6):560-563. doi: 10.1038/nchembio.2383. Nat Chem Biol. 2017. PMID: 28514421 No abstract available.
Phenotypic Identification of a Novel Autophagy Inhibitor Chemotype Targeting Lipid Kinase VPS34.
Robke L, Laraia L, Carnero Corrales MA, Konstantinidis G, Muroi M, Richters A, Winzker M, Engbring T, Tomassi S, Watanabe N, Osada H, Rauh D, Waldmann H, Wu YW, Engel J. Robke L, et al. Among authors: waldmann h. Angew Chem Int Ed Engl. 2017 Jul 3;56(28):8153-8157. doi: 10.1002/anie.201703738. Epub 2017 Jun 12. Angew Chem Int Ed Engl. 2017. PMID: 28544137
1,032 results