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Page 1
Orpinolide disrupts a leukemic dependency on cholesterol transport by inhibiting OSBP.
Cigler M, Imrichova H, Frommelt F, Caramelle L, Depta L, Rukavina A, Kagiou C, Hannich JT, Mayor-Ruiz C, Superti-Furga G, Sievers S, Forrester A, Laraia L, Waldmann H, Winter GE. Cigler M, et al. Among authors: sievers s. Nat Chem Biol. 2024 Jun 21. doi: 10.1038/s41589-024-01614-4. Online ahead of print. Nat Chem Biol. 2024. PMID: 38907113
Synthesis of Indomorphan Pseudo-Natural Product Inhibitors of Glucose Transporters GLUT-1 and -3.
Ceballos J, Schwalfenberg M, Karageorgis G, Reckzeh ES, Sievers S, Ostermann C, Pahl A, Sellstedt M, Nowacki J, Carnero Corrales MA, Wilke J, Laraia L, Tschapalda K, Metz M, Sehr DA, Brand S, Winklhofer K, Janning P, Ziegler S, Waldmann H. Ceballos J, et al. Among authors: sievers s. Angew Chem Int Ed Engl. 2019 Nov 18;58(47):17016-17025. doi: 10.1002/anie.201909518. Epub 2019 Oct 7. Angew Chem Int Ed Engl. 2019. PMID: 31469221 Free PMC article.
Identification of Quinolinols as Activators of TEAD-Dependent Transcription.
Pobbati AV, Mejuch T, Chakraborty S, Karatas H, Bharath SR, Guéret SM, Goy PA, Hahne G, Pahl A, Sievers S, Guccione E, Song H, Waldmann H, Hong W. Pobbati AV, et al. Among authors: sievers s. ACS Chem Biol. 2019 Dec 20;14(12):2909-2921. doi: 10.1021/acschembio.9b00786. Epub 2019 Dec 2. ACS Chem Biol. 2019. PMID: 31742995 Free article.
Image-Based Morphological Profiling Identifies a Lysosomotropic, Iron-Sequestering Autophagy Inhibitor.
Laraia L, Garivet G, Foley DJ, Kaiser N, Müller S, Zinken S, Pinkert T, Wilke J, Corkery D, Pahl A, Sievers S, Janning P, Arenz C, Wu Y, Rodriguez R, Waldmann H. Laraia L, et al. Among authors: sievers s. Angew Chem Int Ed Engl. 2020 Mar 27;59(14):5721-5729. doi: 10.1002/anie.201913712. Epub 2020 Jan 24. Angew Chem Int Ed Engl. 2020. PMID: 31769920 Free PMC article.
Cell-Based Identification of New IDO1 Modulator Chemotypes.
Hennes E, Lampe P, Dötsch L, Bruning N, Pulvermacher LM, Sievers S, Ziegler S, Waldmann H. Hennes E, et al. Among authors: sievers s. Angew Chem Int Ed Engl. 2021 Apr 26;60(18):9869-9874. doi: 10.1002/anie.202016004. Epub 2021 Mar 24. Angew Chem Int Ed Engl. 2021. PMID: 33565680 Free PMC article.
Morphological profiling of small molecules.
Ziegler S, Sievers S, Waldmann H. Ziegler S, et al. Among authors: sievers s. Cell Chem Biol. 2021 Mar 18;28(3):300-319. doi: 10.1016/j.chembiol.2021.02.012. Cell Chem Biol. 2021. PMID: 33740434 Free article. Review.
198 results