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785 results

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Page 1
HIV-1 neutralizing antibodies in SHIV-infected macaques recapitulate structurally divergent modes of human V2 apex recognition with a single D gene.
Roark RS, Habib R, Gorman J, Li H, Connell AJ, Bonsignori M, Guo Y, Hogarty MP, Olia AS, Sowers K, Zhang B, Bibollet-Ruche F, Callaghan S, Carey JW, Cerutti G, Harris DR, He W, Lewis E, Liu T, Mason RD, Park Y, Rando JM, Singh A, Wolff J, Lei QP, Louder MK, Doria-Rose NA, Andrabi R, Saunders KO, Seaman MS, Haynes BF, Kulp DW, Mascola JR, Roederer M, Sheng Z, Hahn BH, Shaw GM, Kwong PD, Shapiro L. Roark RS, et al. Among authors: haynes bf. bioRxiv [Preprint]. 2024 Jun 12:2024.06.11.598384. doi: 10.1101/2024.06.11.598384. bioRxiv. 2024. PMID: 38903070 Free PMC article. Preprint.
SARS-CoV-2 Omicron XBB lineage spike structures, conformations, antigenicity, and receptor recognition.
Zhang QE, Lindenberger J, Parsons R, Thakur B, Parks R, Park CS, Huang X, Sammour S, Janowska K, Spence TN, Edwards RJ, Martin M, Williams WB, Gobeil S, Montefiori DC, Korber B, Saunders KO, Haynes BF, Haynes BF, Henderson R, Acharya P. Zhang QE, et al. Among authors: haynes bf. bioRxiv [Preprint]. 2024 Mar 12:2024.02.12.580004. doi: 10.1101/2024.02.12.580004. bioRxiv. 2024. Update in: Mol Cell. 2024 Jul 25;84(14):2747-2764.e7. doi: 10.1016/j.molcel.2024.06.028 PMID: 38405707 Free PMC article. Updated. Preprint.
A high affinity monoclonal antibody against HLA-E-VL9 enhances natural killer cell anti-tumor killing.
Hwang JK, Marston DJ, Wrapp D, Li D, Tuyishime M, Brackenridge S, Rhodes B, Quastel M, Kapingidza AB, Gater J, Harner A, Wang Y, Rountree W, Ferrari G, Borrow P, McMichael AJ, Gillespie GM, Haynes BF, Azoitei ML. Hwang JK, et al. Among authors: haynes bf. bioRxiv [Preprint]. 2024 Jul 11:2024.07.08.602401. doi: 10.1101/2024.07.08.602401. bioRxiv. 2024. PMID: 39026709 Free PMC article. Preprint.
Transient glycan-shield reduction induces CD4-binding site broadly neutralizing antibodies in SHIV-infected macaques.
Morris DJ, Gorman J, Zhou T, Lora J, Connell AJ, Li H, Liu W, Roark RS, Campion MS, Carey JW, Habib R, Li Y, Martella CL, Park Y, Singh A, Sowers KJ, Teng IT, Wang S, Chohan N, Ding W, Lauer C, Lewis E, Mason RD, Rando JM, Peyton L, Schramm CA, Wagh K, Korber B, Seaman MS, Douek DC, Haynes BF, Kulp DW, Roederer M, Hahn BH, Kwong PD, Shaw GM. Morris DJ, et al. Among authors: haynes bf. bioRxiv [Preprint]. 2024 Dec 30:2024.12.30.630768. doi: 10.1101/2024.12.30.630768. bioRxiv. 2024. PMID: 39803442 Free PMC article. Preprint.
An engineered immunogen activates diverse HIV broadly neutralizing antibody precursors and promotes acquisition of improbable mutations.
Swanson OM, Zhang QE, Van Itallie E, Tian M, Brown AR, Harris C, Kapingidza AB, Rhodes B, Smith LM, Venkatayogi S, Cronin K, Frazier M, Parks R, Bar M, Jiang C, Martin Beem JS, Cheng HL, Davis J, McGovern K, Newman A, Edwards RJ, Cain D, Alam SM, Wiehe K, Saunders KO, Acharya P, Alt F, Haynes BF, Azoitei ML. Swanson OM, et al. Among authors: haynes bf. Sci Transl Med. 2025 Jan 8;17(780):eadr2218. doi: 10.1126/scitranslmed.adr2218. Epub 2025 Jan 8. Sci Transl Med. 2025. PMID: 39772772
Structural and antigenic characterization of novel and diverse Henipavirus glycoproteins.
May AJ, Lella M, Lindenberger J, Berkman A, Dutta M, Barr M, Parks R, Newman A, Huang X, Kumar U, Song K, Ilevbare V, Sammour S, Park CS, Adhikari RD, Devkota P, Janowska K, Liu Y, Scapellato G, Spence TN, Mansouri K, Edwards RJ, Haynes BF, Acharya P. May AJ, et al. Among authors: haynes bf. bioRxiv [Preprint]. 2024 Dec 11:2024.12.11.627382. doi: 10.1101/2024.12.11.627382. bioRxiv. 2024. PMID: 39713338 Free PMC article. Preprint.
Anti-HIV-1 B cell antigen receptor signaling and structure.
Thakur B, Alam J, Cronin K, Patel P, Anasti K, Kane AP, Hossain A, Do H, Mansouri K, Spence TN, Edwards RJ, Janowska K, Lella M, Cook A, Saunders K, Gnanakaran S, Haynes BF, Acharya P, Alam SM. Thakur B, et al. Among authors: haynes bf. bioRxiv [Preprint]. 2024 Nov 15:2024.11.15.623645. doi: 10.1101/2024.11.15.623645. bioRxiv. 2024. PMID: 39605516 Free PMC article. Preprint.
Engineering immunogens that select for specific mutations in HIV broadly neutralizing antibodies.
Henderson R, Anasti K, Manne K, Stalls V, Saunders C, Bililign Y, Williams A, Bubphamala P, Montani M, Kachhap S, Li J, Jaing C, Newman A, Cain DW, Lu X, Venkatayogi S, Berry M, Wagh K, Korber B, Saunders KO, Tian M, Alt F, Wiehe K, Acharya P, Alam SM, Haynes BF. Henderson R, et al. Among authors: haynes bf. Nat Commun. 2024 Nov 3;15(1):9503. doi: 10.1038/s41467-024-53120-9. Nat Commun. 2024. PMID: 39489734 Free PMC article.
Discovery and characterization of a pan-betacoronavirus S2-binding antibody.
Johnson NV, Wall SC, Kramer KJ, Holt CM, Periasamy S, Richardson SI, Manamela NP, Suryadevara N, Andreano E, Paciello I, Pierleoni G, Piccini G, Huang Y, Ge P, Allen JD, Uno N, Shiakolas AR, Pilewski KA, Nargi RS, Sutton RE, Abu-Shmais AA, Parks R, Haynes BF, Carnahan RH, Crowe JE Jr, Montomoli E, Rappuoli R, Bukreyev A, Ross TM, Sautto GA, McLellan JS, Georgiev IS. Johnson NV, et al. Among authors: haynes bf. Structure. 2024 Nov 7;32(11):1893-1909.e11. doi: 10.1016/j.str.2024.08.022. Epub 2024 Sep 25. Structure. 2024. PMID: 39326419
Isolation and characterization of IgG3 glycan-targeting antibodies with exceptional cross-reactivity for diverse viral families.
Vukovich MJ, Shiakolas AR, Lindenberger J, Richardson RA, Bass LE, Barr M, Liu Y, Go EP, Park CS, May AJ, Sammour S, Kambarami C, Huang X, Janowska K, Edwards RJ, Mansouri K, Spence TN, Abu-Shmais AA, Manamela NP, Richardson SI, Leonard SEW, Gripenstraw KR, Setliff I, Saunders KO, Bonami RH, Ross TM, Desaire H, Moore PL, Parks R, Haynes BF, Sheward DJ, Acharya P, Sautto GA, Georgiev IS. Vukovich MJ, et al. Among authors: haynes bf. PLoS Pathog. 2024 Sep 18;20(9):e1012499. doi: 10.1371/journal.ppat.1012499. eCollection 2024 Sep. PLoS Pathog. 2024. PMID: 39292703 Free PMC article.
785 results