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Diastereomers of Coibamide A Show Altered Sec61 Client Selectivity and Ligand-Dependent Activity against Patient-Derived Glioma Stem-like Cells.
Mattos DR, Neves WD, Kitamura T, Pradhan R, Wan X, da Hora CC, Tranter D, Kazemi S, Yu X, Tripathy N, Paavilainen VO, McPhail KL, Oishi S, Badr CE, Ishmael JE. Mattos DR, et al. Among authors: tranter d. ACS Pharmacol Transl Sci. 2024 May 14;7(6):1823-1838. doi: 10.1021/acsptsci.4c00049. eCollection 2024 Jun 14. ACS Pharmacol Transl Sci. 2024. PMID: 38898945
Coibamide A Targets Sec61 to Prevent Biogenesis of Secretory and Membrane Proteins.
Tranter D, Paatero AO, Kawaguchi S, Kazemi S, Serrill JD, Kellosalo J, Vogel WK, Richter U, Mattos DR, Wan X, Thornburg CC, Oishi S, McPhail KL, Ishmael JE, Paavilainen VO. Tranter D, et al. ACS Chem Biol. 2020 Aug 21;15(8):2125-2136. doi: 10.1021/acschembio.0c00325. Epub 2020 Jul 20. ACS Chem Biol. 2020. PMID: 32608972 Free PMC article.
Signal peptide mimicry primes Sec61 for client-selective inhibition.
Rehan S, Tranter D, Sharp PP, Craven GB, Lowe E, Anderl JL, Muchamuel T, Abrishami V, Kuivanen S, Wenzell NA, Jennings A, Kalyanaraman C, Strandin T, Javanainen M, Vapalahti O, Jacobson MP, McMinn D, Kirk CJ, Huiskonen JT, Taunton J, Paavilainen VO. Rehan S, et al. Among authors: tranter d. Nat Chem Biol. 2023 Sep;19(9):1054-1062. doi: 10.1038/s41589-023-01326-1. Epub 2023 May 11. Nat Chem Biol. 2023. PMID: 37169961 Free PMC article.
Molecular view of ER membrane remodeling by the Sec61/TRAP translocon.
Karki S, Javanainen M, Rehan S, Tranter D, Kellosalo J, Huiskonen JT, Happonen L, Paavilainen V. Karki S, et al. Among authors: tranter d. EMBO Rep. 2023 Dec 6;24(12):e57910. doi: 10.15252/embr.202357910. Epub 2023 Nov 20. EMBO Rep. 2023. PMID: 37983950 Free PMC article.
Ipomoeassin F Binds Sec61α to Inhibit Protein Translocation.
Zong G, Hu Z, O'Keefe S, Tranter D, Iannotti MJ, Baron L, Hall B, Corfield K, Paatero AO, Henderson MJ, Roboti P, Zhou J, Sun X, Govindarajan M, Rohde JM, Blanchard N, Simmonds R, Inglese J, Du Y, Demangel C, High S, Paavilainen VO, Shi WQ. Zong G, et al. Among authors: tranter d. J Am Chem Soc. 2019 May 29;141(21):8450-8461. doi: 10.1021/jacs.8b13506. Epub 2019 May 15. J Am Chem Soc. 2019. PMID: 31059257 Free PMC article.
Snapshots of actin and tubulin folding inside the TRiC chaperonin.
Kelly JJ, Tranter D, Pardon E, Chi G, Kramer H, Happonen L, Knee KM, Janz JM, Steyaert J, Bulawa C, Paavilainen VO, Huiskonen JT, Yue WW. Kelly JJ, et al. Among authors: tranter d. Nat Struct Mol Biol. 2022 May;29(5):420-429. doi: 10.1038/s41594-022-00755-1. Epub 2022 Apr 21. Nat Struct Mol Biol. 2022. PMID: 35449234 Free PMC article.
SARS-CoV-2 Exposure and Infection Among Health Care Personnel - Minnesota, March 6-July 11, 2020.
Fell A, Beaudoin A, D'Heilly P, Mumm E, Cole C, Tourdot L, Ruhland A, Klumb C, Rounds J, Bailey B, Liverseed G, Peterson M, Mahoehney JP, Ireland M, Bye M, Setty S, Leeds M, Taylor J, Holzbauer S; Minnesota Department of Health COVID-19 HCW Monitoring Response Team; Minnesota Department of Health COVID-19 Response Task Force. Fell A, et al. MMWR Morb Mortal Wkly Rep. 2020 Oct 30;69(43):1605-1610. doi: 10.15585/mmwr.mm6943a5. MMWR Morb Mortal Wkly Rep. 2020. PMID: 33119557 Free PMC article.
G Protein-Coupled Receptors Contain Two Conserved Packing Clusters.
Sanchez-Reyes OB, Cooke ALG, Tranter DB, Rashid D, Eilers M, Reeves PJ, Smith SO. Sanchez-Reyes OB, et al. Among authors: tranter db. Biophys J. 2017 Jun 6;112(11):2315-2326. doi: 10.1016/j.bpj.2017.04.051. Biophys J. 2017. PMID: 28591604 Free PMC article.
30 results