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42,487 results

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AMPK targets PDZD8 to trigger carbon source shift from glucose to glutamine.
Li M, Wang Y, Wei X, Cai WF, Wu J, Zhu M, Wang Y, Liu YH, Xiong J, Qu Q, Chen Y, Tian X, Yao L, Xie R, Li X, Chen S, Huang X, Zhang C, Xie C, Wu Y, Xu Z, Zhang B, Jiang B, Wang ZC, Li Q, Li G, Lin SY, Yu L, Piao HL, Deng X, Han J, Zhang CS, Lin SC. Li M, et al. Among authors: zhang b, zhang c, zhang cs. Cell Res. 2024 Oct;34(10):683-706. doi: 10.1038/s41422-024-00985-6. Epub 2024 Jun 19. Cell Res. 2024. PMID: 38898113 Free PMC article.
Discovery of methyl 3-((2-((1-(dimethylglycyl)-5-methoxyindolin-6-yl)amino)-5-(trifluoro-methyl) pyrimidin-4-yl)amino)thiophene-2-carboxylate as a potent and selective polo-like kinase 1 (PLK1) inhibitor for combating hepatocellular carcinoma.
Deng Z, Chen G, Liu S, Li Y, Zhong J, Zhang B, Li L, Huang H, Wang Z, Xu Q, Deng X. Deng Z, et al. Among authors: zhang b. Eur J Med Chem. 2020 Nov 15;206:112697. doi: 10.1016/j.ejmech.2020.112697. Epub 2020 Aug 8. Eur J Med Chem. 2020. PMID: 32814244
Low-dose metformin targets the lysosomal AMPK pathway through PEN2.
Ma T, Tian X, Zhang B, Li M, Wang Y, Yang C, Wu J, Wei X, Qu Q, Yu Y, Long S, Feng JW, Li C, Zhang C, Xie C, Wu Y, Xu Z, Chen J, Yu Y, Huang X, He Y, Yao L, Zhang L, Zhu M, Wang W, Wang ZC, Zhang M, Bao Y, Jia W, Lin SY, Ye Z, Piao HL, Deng X, Zhang CS, Lin SC. Ma T, et al. Among authors: zhang l, zhang m, zhang b, zhang c, zhang cs. Nature. 2022 Mar;603(7899):159-165. doi: 10.1038/s41586-022-04431-8. Epub 2022 Feb 23. Nature. 2022. PMID: 35197629 Free PMC article.
The aldolase inhibitor aldometanib mimics glucose starvation to activate lysosomal AMPK.
Zhang CS, Li M, Wang Y, Li X, Zong Y, Long S, Zhang M, Feng JW, Wei X, Liu YH, Zhang B, Wu J, Zhang C, Lian W, Ma T, Tian X, Qu Q, Yu Y, Xiong J, Liu DT, Wu Z, Zhu M, Xie C, Wu Y, Xu Z, Yang C, Chen J, Huang G, He Q, Huang X, Zhang L, Sun X, Liu Q, Ghafoor A, Gui F, Zheng K, Wang W, Wang ZC, Yu Y, Zhao Q, Lin SY, Wang ZX, Piao HL, Deng X, Lin SC. Zhang CS, et al. Among authors: zhang l, zhang m, zhang b, zhang c. Nat Metab. 2022 Oct;4(10):1369-1401. doi: 10.1038/s42255-022-00640-7. Epub 2022 Oct 10. Nat Metab. 2022. PMID: 36217034 Free PMC article.
Lithocholic acid phenocopies anti-ageing effects of calorie restriction.
Qu Q, Chen Y, Wang Y, Long S, Wang W, Yang HY, Li M, Tian X, Wei X, Liu YH, Xu S, Zhang C, Zhu M, Lam SM, Wu J, Yun C, Chen J, Xue S, Zhang B, Zheng ZZ, Piao HL, Jiang C, Guo H, Shui G, Deng X, Zhang CS, Lin SC. Qu Q, et al. Among authors: zhang b, zhang c, zhang cs. Nature. 2024 Dec 18. doi: 10.1038/s41586-024-08329-5. Online ahead of print. Nature. 2024. PMID: 39695227
Lithocholic acid binds TULP3 to activate sirtuins and AMPK to slow down ageing.
Qu Q, Chen Y, Wang Y, Wang W, Long S, Yang HY, Wu J, Li M, Tian X, Wei X, Liu YH, Xu S, Xiong J, Yang C, Wu Z, Huang X, Xie C, Wu Y, Xu Z, Zhang C, Zhang B, Feng JW, Chen J, Feng Y, Fang H, Lin L, Xie ZK, Sun B, Tian H, Yu Y, Piao HL, Xie XS, Deng X, Zhang CS, Lin SC. Qu Q, et al. Among authors: zhang b, zhang c, zhang cs. Nature. 2024 Dec 18. doi: 10.1038/s41586-024-08348-2. Online ahead of print. Nature. 2024. PMID: 39695235
Discovery of 4-methyl-N-(4-((4-methylpiperazin- 1-yl)methyl)-3-(trifluoromethyl)phenyl)-3-((6-(pyridin-3-yl)-1H-pyrazolo[3,4-d]pyrimidin-4-yl)-oxy)benzamide as a potent inhibitor of RET and its gatekeeper mutant.
Li X, Su J, Yang Y, Lian W, Deng Z, Yang Z, Chen G, Zhang B, Dong C, Liu X, Li L, Wang Z, Hu Z, Xu Q, Deng X. Li X, et al. Among authors: zhang b. Eur J Med Chem. 2020 Dec 1;207:112755. doi: 10.1016/j.ejmech.2020.112755. Epub 2020 Aug 22. Eur J Med Chem. 2020. PMID: 32882611
PIKfyve inhibitors against SARS-CoV-2 and its variants including Omicron.
Su J, Zheng J, Huang W, Zhang Y, Lv C, Zhang B, Jiang L, Cheng T, Yuan Q, Xia N, Zhang J, Li L, Li L, Deng X. Su J, et al. Among authors: zhang b, zhang j, zhang y. Signal Transduct Target Ther. 2022 May 24;7(1):167. doi: 10.1038/s41392-022-01025-8. Signal Transduct Target Ther. 2022. PMID: 35610213 Free PMC article. No abstract available.
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