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Page 1
Suppressed basal mitophagy drives cellular aging phenotypes that can be reversed by a p62-targeting small molecule.
Kelly G, Kataura T, Panek J, Ma G, Salmonowicz H, Davis A, Kendall H, Brookes C, Ayine-Tora DM, Banks P, Nelson G, Dobby L, Pitrez PR, Booth L, Costello L, Richardson GD, Lovat P, Przyborski S, Ferreira L, Greaves L, Szczepanowska K, von Zglinicki T, Miwa S, Brown M, Flagler M, Oblong JE, Bascom CC, Carroll B, Reynisson J, Korolchuk VI. Kelly G, et al. Among authors: szczepanowska k. Dev Cell. 2024 Aug 5;59(15):1924-1939.e7. doi: 10.1016/j.devcel.2024.04.020. Epub 2024 Jun 18. Dev Cell. 2024. PMID: 38897197 Free article.
Author Correction: Apoptotic stress causes mtDNA release during senescence and drives the SASP.
Victorelli S, Salmonowicz H, Chapman J, Martini H, Vizioli MG, Riley JS, Cloix C, Hall-Younger E, Machado Espindola-Netto J, Jurk D, Lagnado AB, Sales Gomez L, Farr JN, Saul D, Reed R, Kelly G, Eppard M, Greaves LC, Dou Z, Pirius N, Szczepanowska K, Porritt RA, Huang H, Huang TY, Mann DA, Masuda CA, Khosla S, Dai H, Kaufmann SH, Zacharioudakis E, Gavathiotis E, LeBrasseur NK, Lei X, Sainz AG, Korolchuk VI, Adams PD, Shadel GS, Tait SWG, Passos JF. Victorelli S, et al. Among authors: szczepanowska k. Nature. 2024 Jan;625(7995):E15. doi: 10.1038/s41586-023-07002-7. Nature. 2024. PMID: 38168624 Free PMC article. No abstract available.
Mitochondrial dysfunction abrogates dietary lipid processing in enterocytes.
Moschandrea C, Kondylis V, Evangelakos I, Herholz M, Schneider F, Schmidt C, Yang M, Ehret S, Heine M, Jaeckstein MY, Szczepanowska K, Schwarzer R, Baumann L, Bock T, Nikitopoulou E, Brodesser S, Krüger M, Frezza C, Heeren J, Trifunovic A, Pasparakis M. Moschandrea C, et al. Among authors: szczepanowska k. Nature. 2024 Jan;625(7994):385-392. doi: 10.1038/s41586-023-06857-0. Epub 2023 Dec 20. Nature. 2024. PMID: 38123683 Free PMC article.
Apoptotic stress causes mtDNA release during senescence and drives the SASP.
Victorelli S, Salmonowicz H, Chapman J, Martini H, Vizioli MG, Riley JS, Cloix C, Hall-Younger E, Machado Espindola-Netto J, Jurk D, Lagnado AB, Sales Gomez L, Farr JN, Saul D, Reed R, Kelly G, Eppard M, Greaves LC, Dou Z, Pirius N, Szczepanowska K, Porritt RA, Huang H, Huang TY, Mann DA, Masuda CA, Khosla S, Dai H, Kaufmann SH, Zacharioudakis E, Gavathiotis E, LeBrasseur NK, Lei X, Sainz AG, Korolchuk VI, Adams PD, Shadel GS, Tait SWG, Passos JF. Victorelli S, et al. Among authors: szczepanowska k. Nature. 2023 Oct;622(7983):627-636. doi: 10.1038/s41586-023-06621-4. Epub 2023 Oct 11. Nature. 2023. PMID: 37821702 Free PMC article.
AIFM1 is a component of the mitochondrial disulfide relay that drives complex I assembly through efficient import of NDUFS5.
Salscheider SL, Gerlich S, Cabrera-Orefice A, Peker E, Rothemann RA, Murschall LM, Finger Y, Szczepanowska K, Ahmadi ZA, Guerrero-Castillo S, Erdogan A, Becker M, Ali M, Habich M, Petrungaro C, Burdina N, Schwarz G, Klußmann M, Neundorf I, Stroud DA, Ryan MT, Trifunovic A, Brandt U, Riemer J. Salscheider SL, et al. Among authors: szczepanowska k. EMBO J. 2022 Sep 1;41(17):e110784. doi: 10.15252/embj.2022110784. Epub 2022 Jul 20. EMBO J. 2022. PMID: 35859387 Free PMC article.
Remission of obesity and insulin resistance is not sufficient to restore mitochondrial homeostasis in visceral adipose tissue.
Gonzalez-Franquesa A, Gama-Perez P, Kulis M, Szczepanowska K, Dahdah N, Moreno-Gomez S, Latorre-Pellicer A, Fernández-Ruiz R, Aguilar-Mogas A, Hoffman A, Monelli E, Samino S, Miró-Blanch J, Oemer G, Duran X, Sanchez-Rebordelo E, Schneeberger M, Obach M, Montane J, Castellano G, Chapaprieta V, Sun W, Navarro L, Prieto I, Castaño C, Novials A, Gomis R, Monsalve M, Claret M, Graupera M, Soria G, Wolfrum C, Vendrell J, Fernández-Veledo S, Enríquez JA, Carracedo A, Perales JC, Nogueiras R, Herrero L, Trifunovic A, Keller MA, Yanes O, Sales-Pardo M, Guimerà R, Blüher M, Martín-Subero JI, Garcia-Roves PM. Gonzalez-Franquesa A, et al. Among authors: szczepanowska k. Redox Biol. 2022 Aug;54:102353. doi: 10.1016/j.redox.2022.102353. Epub 2022 Jun 24. Redox Biol. 2022. PMID: 35777200 Free PMC article.
FGF21 modulates mitochondrial stress response in cardiomyocytes only under mild mitochondrial dysfunction.
Croon M, Szczepanowska K, Popovic M, Lienkamp C, Senft K, Brandscheid CP, Bock T, Gnatzy-Feik L, Ashurov A, Acton RJ, Kaul H, Pujol C, Rosenkranz S, Krüger M, Trifunovic A. Croon M, et al. Among authors: szczepanowska k. Sci Adv. 2022 Apr 8;8(14):eabn7105. doi: 10.1126/sciadv.abn7105. Epub 2022 Apr 6. Sci Adv. 2022. PMID: 35385313 Free PMC article.
Ovarian carcinoma immunoreactive antigen-like protein 2 (OCIAD2) is a novel complex III-specific assembly factor in mitochondria.
Chojnacka KJ, Elancheliyan P, Mussulini BHM, Mohanraj K, Callegari S, Gosk A, Banach T, Góral T, Szczepanowska K, Rehling P, Serwa RA, Chacinska A. Chojnacka KJ, et al. Among authors: szczepanowska k. Mol Biol Cell. 2022 Apr 1;33(4):ar29. doi: 10.1091/mbc.E21-03-0143. Epub 2022 Jan 26. Mol Biol Cell. 2022. PMID: 35080992 Free PMC article.
Small molecule inhibitors of the mitochondrial ClpXP protease possess cytostatic potential and re-sensitize chemo-resistant cancers.
Meßner M, Mandl MM, Hackl MW, Reinhardt T, Ardelt MA, Szczepanowska K, Frädrich JE, Waschke J, Jeremias I, Fux A, Stahl M, Vollmar AM, Sieber SA, Pachmayr J. Meßner M, et al. Among authors: szczepanowska k. Sci Rep. 2021 May 27;11(1):11185. doi: 10.1038/s41598-021-90801-7. Sci Rep. 2021. PMID: 34045646 Free PMC article.
25 results