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Suppressed basal mitophagy drives cellular aging phenotypes that can be reversed by a p62-targeting small molecule.
Kelly G, Kataura T, Panek J, Ma G, Salmonowicz H, Davis A, Kendall H, Brookes C, Ayine-Tora DM, Banks P, Nelson G, Dobby L, Pitrez PR, Booth L, Costello L, Richardson GD, Lovat P, Przyborski S, Ferreira L, Greaves L, Szczepanowska K, von Zglinicki T, Miwa S, Brown M, Flagler M, Oblong JE, Bascom CC, Carroll B, Reynisson J, Korolchuk VI. Kelly G, et al. Among authors: richardson gd. Dev Cell. 2024 Aug 5;59(15):1924-1939.e7. doi: 10.1016/j.devcel.2024.04.020. Epub 2024 Jun 18. Dev Cell. 2024. PMID: 38897197 Free article.
Rapamycin improves healthspan but not inflammaging in nfκb1-/- mice.
Correia-Melo C, Birch J, Fielder E, Rahmatika D, Taylor J, Chapman J, Lagnado A, Carroll BM, Miwa S, Richardson G, Jurk D, Oakley F, Mann J, Mann DA, Korolchuk VI, Passos JF. Correia-Melo C, et al. Aging Cell. 2019 Feb;18(1):e12882. doi: 10.1111/acel.12882. Epub 2018 Nov 23. Aging Cell. 2019. PMID: 30468013 Free PMC article.
Anthracycline-induced cardiotoxicity and senescence.
Booth LK, Redgrave RE, Folaranmi O, Gill JH, Richardson GD. Booth LK, et al. Among authors: richardson gd. Front Aging. 2022 Nov 14;3:1058435. doi: 10.3389/fragi.2022.1058435. eCollection 2022. Front Aging. 2022. PMID: 36452034 Free PMC article. Review.
New Horizons in cellular senescence for clinicians.
Witham MD, Granic A, Miwa S, Passos JF, Richardson GD, Sayer AA. Witham MD, et al. Among authors: richardson gd. Age Ageing. 2023 Jul 1;52(7):afad127. doi: 10.1093/ageing/afad127. Age Ageing. 2023. PMID: 37466640 Free PMC article.
Multimorbidity is associated with myocardial DNA damage, nucleolar stress, dysregulated energy metabolism, and senescence in cardiovascular disease.
Tomkova K, Roman M, Adebayo AS, Sheikh S, Yusoff S, Gulston M, Joel-David L, Lai FY, Murgia A, Eagle-Hemming B, Aujla H, Chad T, Richardson GD, Griffin JL, Murphy GJ, Woźniak MJ. Tomkova K, et al. Among authors: richardson gd. NPJ Aging. 2024 Nov 27;10(1):58. doi: 10.1038/s41514-024-00183-z. NPJ Aging. 2024. PMID: 39604391 Free PMC article.
Identifying optimal reference genes for qRT-PCR in human myocardial tissues.
Camacho-Encina M, Booth LK, Redgrave R, Honkanen-Scott M, Scott WE 3rd, Martin-Ruiz C, MacGowan G, Richardson S, Dark J, Tual-Chalot S, Richardson GD. Camacho-Encina M, et al. Among authors: richardson gd. Cardiovasc Res. 2024 Sep 6:cvae194. doi: 10.1093/cvr/cvae194. Online ahead of print. Cardiovasc Res. 2024. PMID: 39238367 No abstract available.
44 results