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Suppressed basal mitophagy drives cellular aging phenotypes that can be reversed by a p62-targeting small molecule.
Kelly G, Kataura T, Panek J, Ma G, Salmonowicz H, Davis A, Kendall H, Brookes C, Ayine-Tora DM, Banks P, Nelson G, Dobby L, Pitrez PR, Booth L, Costello L, Richardson GD, Lovat P, Przyborski S, Ferreira L, Greaves L, Szczepanowska K, von Zglinicki T, Miwa S, Brown M, Flagler M, Oblong JE, Bascom CC, Carroll B, Reynisson J, Korolchuk VI. Kelly G, et al. Among authors: nelson g. Dev Cell. 2024 Aug 5;59(15):1924-1939.e7. doi: 10.1016/j.devcel.2024.04.020. Epub 2024 Jun 18. Dev Cell. 2024. PMID: 38897197 Free article.
Persistent mTORC1 signaling in cell senescence results from defects in amino acid and growth factor sensing.
Carroll B, Nelson G, Rabanal-Ruiz Y, Kucheryavenko O, Dunhill-Turner NA, Chesterman CC, Zahari Q, Zhang T, Conduit SE, Mitchell CA, Maddocks ODK, Lovat P, von Zglinicki T, Korolchuk VI. Carroll B, et al. Among authors: nelson g. J Cell Biol. 2017 Jul 3;216(7):1949-1957. doi: 10.1083/jcb.201610113. Epub 2017 May 31. J Cell Biol. 2017. PMID: 28566325 Free PMC article.
The mTORC1-autophagy pathway is a target for senescent cell elimination.
Kucheryavenko O, Nelson G, von Zglinicki T, Korolchuk VI, Carroll B. Kucheryavenko O, et al. Among authors: nelson g. Biogerontology. 2019 Jun;20(3):331-335. doi: 10.1007/s10522-019-09802-9. Epub 2019 Feb 23. Biogerontology. 2019. PMID: 30798505 Free PMC article.
Monitoring DNA damage during cell senescence.
Nelson G, von Zglinicki T. Nelson G, et al. Methods Mol Biol. 2013;965:197-213. doi: 10.1007/978-1-62703-239-1_13. Methods Mol Biol. 2013. PMID: 23296660
DNA damage foci in mitosis are devoid of 53BP1.
Nelson G, Buhmann M, von Zglinicki T. Nelson G, et al. Cell Cycle. 2009 Oct 15;8(20):3379-83. doi: 10.4161/cc.8.20.9857. Epub 2009 Oct 19. Cell Cycle. 2009. PMID: 19806024
DNA damage response and cellular senescence in tissues of aging mice.
Wang C, Jurk D, Maddick M, Nelson G, Martin-Ruiz C, von Zglinicki T. Wang C, et al. Among authors: nelson g. Aging Cell. 2009 Jun;8(3):311-23. doi: 10.1111/j.1474-9726.2009.00481.x. Epub 2009 Apr 9. Aging Cell. 2009. PMID: 19627270 Free article.
SQSTM1/p62 mediates crosstalk between autophagy and the UPS in DNA repair.
Hewitt G, Carroll B, Sarallah R, Correia-Melo C, Ogrodnik M, Nelson G, Otten EG, Manni D, Antrobus R, Morgan BA, von Zglinicki T, Jurk D, Seluanov A, Gorbunova V, Johansen T, Passos JF, Korolchuk VI. Hewitt G, et al. Among authors: nelson g. Autophagy. 2016 Oct 2;12(10):1917-1930. doi: 10.1080/15548627.2016.1210368. Epub 2016 Jul 8. Autophagy. 2016. PMID: 27391408 Free PMC article.
Metabolic dysfunction in human skin: Restoration of mitochondrial integrity and metabolic output by nicotinamide (niacinamide) in primary dermal fibroblasts from older aged donors.
Oblong JE, Bowman A, Rovito HA, Jarrold BB, Sherrill JD, Black MR, Nelson G, Kimball AB, Birch-Machin MA. Oblong JE, et al. Among authors: nelson g. Aging Cell. 2020 Oct;19(10):e13248. doi: 10.1111/acel.13248. Epub 2020 Sep 29. Aging Cell. 2020. PMID: 32990346 Free PMC article.
A senescent cell bystander effect: senescence-induced senescence.
Nelson G, Wordsworth J, Wang C, Jurk D, Lawless C, Martin-Ruiz C, von Zglinicki T. Nelson G, et al. Aging Cell. 2012 Apr;11(2):345-9. doi: 10.1111/j.1474-9726.2012.00795.x. Epub 2012 Feb 9. Aging Cell. 2012. PMID: 22321662 Free PMC article.
Bioengineering the microanatomy of human skin.
Roger M, Fullard N, Costello L, Bradbury S, Markiewicz E, O'Reilly S, Darling N, Ritchie P, Määttä A, Karakesisoglou I, Nelson G, von Zglinicki T, Dicolandrea T, Isfort R, Bascom C, Przyborski S. Roger M, et al. Among authors: nelson g. J Anat. 2019 Apr;234(4):438-455. doi: 10.1111/joa.12942. Epub 2019 Feb 10. J Anat. 2019. PMID: 30740672 Free PMC article.
1,908 results