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Suppressed basal mitophagy drives cellular aging phenotypes that can be reversed by a p62-targeting small molecule.
Kelly G, Kataura T, Panek J, Ma G, Salmonowicz H, Davis A, Kendall H, Brookes C, Ayine-Tora DM, Banks P, Nelson G, Dobby L, Pitrez PR, Booth L, Costello L, Richardson GD, Lovat P, Przyborski S, Ferreira L, Greaves L, Szczepanowska K, von Zglinicki T, Miwa S, Brown M, Flagler M, Oblong JE, Bascom CC, Carroll B, Reynisson J, Korolchuk VI. Kelly G, et al. Dev Cell. 2024 Aug 5;59(15):1924-1939.e7. doi: 10.1016/j.devcel.2024.04.020. Epub 2024 Jun 18. Dev Cell. 2024. PMID: 38897197 Free article.
The pROS of Autophagy in Neuronal Health.
Sedlackova L, Kelly G, Korolchuk VI. Sedlackova L, et al. Among authors: kelly g. J Mol Biol. 2020 Apr 3;432(8):2546-2559. doi: 10.1016/j.jmb.2020.01.020. Epub 2020 Jan 30. J Mol Biol. 2020. PMID: 32006535 Free PMC article. Review.
Autophagy promotes cell survival by maintaining NAD levels.
Kataura T, Sedlackova L, Otten EG, Kumari R, Shapira D, Scialo F, Stefanatos R, Ishikawa KI, Kelly G, Seranova E, Sun C, Maetzel D, Kenneth N, Trushin S, Zhang T, Trushina E, Bascom CC, Tasseff R, Isfort RJ, Oblong JE, Miwa S, Lazarou M, Jaenisch R, Imoto M, Saiki S, Papamichos-Chronakis M, Manjithaya R, Maddocks ODK, Sanz A, Sarkar S, Korolchuk VI. Kataura T, et al. Among authors: kelly g. Dev Cell. 2022 Nov 21;57(22):2584-2598.e11. doi: 10.1016/j.devcel.2022.10.008. Dev Cell. 2022. PMID: 36413951 Free PMC article.
Apoptotic stress causes mtDNA release during senescence and drives the SASP.
Victorelli S, Salmonowicz H, Chapman J, Martini H, Vizioli MG, Riley JS, Cloix C, Hall-Younger E, Machado Espindola-Netto J, Jurk D, Lagnado AB, Sales Gomez L, Farr JN, Saul D, Reed R, Kelly G, Eppard M, Greaves LC, Dou Z, Pirius N, Szczepanowska K, Porritt RA, Huang H, Huang TY, Mann DA, Masuda CA, Khosla S, Dai H, Kaufmann SH, Zacharioudakis E, Gavathiotis E, LeBrasseur NK, Lei X, Sainz AG, Korolchuk VI, Adams PD, Shadel GS, Tait SWG, Passos JF. Victorelli S, et al. Among authors: kelly g. Nature. 2023 Oct;622(7983):627-636. doi: 10.1038/s41586-023-06621-4. Epub 2023 Oct 11. Nature. 2023. PMID: 37821702 Free PMC article.
Author Correction: Apoptotic stress causes mtDNA release during senescence and drives the SASP.
Victorelli S, Salmonowicz H, Chapman J, Martini H, Vizioli MG, Riley JS, Cloix C, Hall-Younger E, Machado Espindola-Netto J, Jurk D, Lagnado AB, Sales Gomez L, Farr JN, Saul D, Reed R, Kelly G, Eppard M, Greaves LC, Dou Z, Pirius N, Szczepanowska K, Porritt RA, Huang H, Huang TY, Mann DA, Masuda CA, Khosla S, Dai H, Kaufmann SH, Zacharioudakis E, Gavathiotis E, LeBrasseur NK, Lei X, Sainz AG, Korolchuk VI, Adams PD, Shadel GS, Tait SWG, Passos JF. Victorelli S, et al. Among authors: kelly g. Nature. 2024 Jan;625(7995):E15. doi: 10.1038/s41586-023-07002-7. Nature. 2024. PMID: 38168624 Free PMC article. No abstract available.
The National Joint Registry Data Quality Audit of elbow arthroplasty.
Hamoodi Z, Shapiro J, Sayers A, Whitehouse MR, Watts AC; NJR DQA-Elbows Collaborators; Abbott J, Abbott S, Adebayo O, Ahmad K, Ahrens P, Akinfala M, Al-Hadithy N, Al-Najjar M, Amirfeyz R, Ankarath S, Ashton F, Aulton K, Auplish S, Austin J, Ayeko S, Azhar R, Bahia R, Baines S, Baldomir M, Barai S, Barkham B, Barrett E, Batten T, Bavan L, Baxter J, Beaumont S, Bentley J, Bhabra G, Bhat M, Bhatt A, Bhingraj M, Bhutta A, Bingham S, Blastland J, Boardman D, Boateng M, Bojarska K, Boksh K, Booker S, Borreshi S, Bould M, Boulton L, Brannan L, Breidaka Z, Brereton R, Brinsden M, Brooker J, Brookes S, Broux C, Brown E, Browne J, Bryant R, Buchanan J, Buck L, Burnett K, Burrows M, Burt J, Burton D, Butt U, Campaner B, Candal-Couto J, Carvell H, Chakravarthy J, Chatterji S, Chaudhury S, Chauhan GS, Chojnowski A, Cittambalam J, Clark D, Gosia Clarke M, Clarke B, Clelland A, Cochrane R, Colbridge K, Cook H, Cooper B, Correa E, Craven J, Crawford J, Curtis S, Cuthbert R, Dainton J, Dale L, Davies S, Davis J, Davis V, Dean B, Dehler T, Dennis S, Der Tavitian J, Desai A, Dhillon SS, Dias R, Dickinson G, Dirckx M, Dixon O, Docker C, Dodenhoff R, Domos P, Draviaraj K, Drew S, Duff C, Duffin S, Dur… See abstract for full author list ➔ Hamoodi Z, et al. Among authors: kelly g. Bone Joint J. 2024 Dec 1;106-B(12):1461-1468. doi: 10.1302/0301-620X.106B12.BJJ-2023-1372.R1. Bone Joint J. 2024. PMID: 39618239
1,239 results