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Suppressed basal mitophagy drives cellular aging phenotypes that can be reversed by a p62-targeting small molecule.
Kelly G, Kataura T, Panek J, Ma G, Salmonowicz H, Davis A, Kendall H, Brookes C, Ayine-Tora DM, Banks P, Nelson G, Dobby L, Pitrez PR, Booth L, Costello L, Richardson GD, Lovat P, Przyborski S, Ferreira L, Greaves L, Szczepanowska K, von Zglinicki T, Miwa S, Brown M, Flagler M, Oblong JE, Bascom CC, Carroll B, Reynisson J, Korolchuk VI. Kelly G, et al. Among authors: booth l. Dev Cell. 2024 Aug 5;59(15):1924-1939.e7. doi: 10.1016/j.devcel.2024.04.020. Epub 2024 Jun 18. Dev Cell. 2024. PMID: 38897197 Free article.
Anthracycline-induced cardiotoxicity and senescence.
Booth LK, Redgrave RE, Folaranmi O, Gill JH, Richardson GD. Booth LK, et al. Front Aging. 2022 Nov 14;3:1058435. doi: 10.3389/fragi.2022.1058435. eCollection 2022. Front Aging. 2022. PMID: 36452034 Free PMC article. Review.
Senescent cardiomyocytes contribute to cardiac dysfunction following myocardial infarction.
Redgrave R, Dookun E, Booth L, Folaranm O, Tual-Chalot S, Gill J, Owens A, Spyridopoulos I, Passos J, Richardson G. Redgrave R, et al. Among authors: booth l. Res Sq [Preprint]. 2023 Apr 10:rs.3.rs-2776501. doi: 10.21203/rs.3.rs-2776501/v1. Res Sq. 2023. Update in: NPJ Aging. 2023 Jun 14;9(1):15. doi: 10.1038/s41514-023-00113-5 PMID: 37090497 Free PMC article. Updated. Preprint.
Identifying optimal reference genes for qRT-PCR in human myocardial tissues.
Camacho-Encina M, Booth LK, Redgrave R, Honkanen-Scott M, Scott WE 3rd, Martin-Ruiz C, MacGowan G, Richardson S, Dark J, Tual-Chalot S, Richardson GD. Camacho-Encina M, et al. Among authors: booth lk. Cardiovasc Res. 2024 Sep 6:cvae194. doi: 10.1093/cvr/cvae194. Online ahead of print. Cardiovasc Res. 2024. PMID: 39238367 No abstract available.
424 results