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The combination of three CD4-induced antibodies targeting highly conserved Env regions with a small CD4-mimetic achieves potent ADCC activity.
Marchitto L, Richard J, Prévost J, Tauzin A, Yang D, Chiu T, Chen HC, Díaz-Salinas MA, Nayrac M, Benlarbi M, Beaudoin-Bussières G, Anand SP, Dionne K, Bélanger É, Chatterjee D, Medjahed H, Bourassa C, Tolbert WD, Hahn BH, Munro JB, Pazgier M, Smith AB 3rd, Finzi A. Marchitto L, et al. Among authors: prevost j. bioRxiv [Preprint]. 2024 Jun 7:2024.06.07.597978. doi: 10.1101/2024.06.07.597978. bioRxiv. 2024. Update in: J Virol. 2024 Oct 22;98(10):e0101624. doi: 10.1128/jvi.01016-24 PMID: 38895270 Free PMC article. Updated. Preprint.
A Highly Conserved Residue of the HIV-1 gp120 Inner Domain Is Important for Antibody-Dependent Cellular Cytotoxicity Responses Mediated by Anti-cluster A Antibodies.
Ding S, Veillette M, Coutu M, Prévost J, Scharf L, Bjorkman PJ, Ferrari G, Robinson JE, Stürzel C, Hahn BH, Sauter D, Kirchhoff F, Lewis GK, Pazgier M, Finzi A. Ding S, et al. Among authors: prevost j. J Virol. 2015 Dec 4;90(4):2127-34. doi: 10.1128/JVI.02779-15. Print 2016 Feb 15. J Virol. 2015. PMID: 26637462 Free PMC article.
A Highly Conserved gp120 Inner Domain Residue Modulates Env Conformation and Trimer Stability.
Ding S, Tolbert WD, Prévost J, Pacheco B, Coutu M, Debbeche O, Xiang SH, Pazgier M, Finzi A. Ding S, et al. Among authors: prevost j. J Virol. 2016 Sep 12;90(19):8395-409. doi: 10.1128/JVI.01068-16. Print 2016 Oct 1. J Virol. 2016. PMID: 27384653 Free PMC article.
Finzi, S. H. Xiang, B. Pacheco, L. Wang, J. Haight, et al., Mol Cell 37:656-667, 2010, http://dx.doi.org/10.1016/j.molcel.2010.02.012; A. ...Ding, M. Veillette, M. Coutu, J. Prevost, L. Scharf, et al., 2016, J Virol 90:2127-2134, http://dx.doi.o …
Finzi, S. H. Xiang, B. Pacheco, L. Wang, J. Haight, et al., Mol Cell 37:656-667, 2010, http://dx.doi.org/10.1016/j.molcel.2010 …
Co-receptor Binding Site Antibodies Enable CD4-Mimetics to Expose Conserved Anti-cluster A ADCC Epitopes on HIV-1 Envelope Glycoproteins.
Richard J, Pacheco B, Gohain N, Veillette M, Ding S, Alsahafi N, Tolbert WD, Prévost J, Chapleau JP, Coutu M, Jia M, Brassard N, Park J, Courter JR, Melillo B, Martin L, Tremblay C, Hahn BH, Kaufmann DE, Wu X, Smith AB 3rd, Sodroski J, Pazgier M, Finzi A. Richard J, et al. Among authors: prevost j. EBioMedicine. 2016 Oct;12:208-218. doi: 10.1016/j.ebiom.2016.09.004. Epub 2016 Sep 9. EBioMedicine. 2016. PMID: 27633463 Free PMC article.
BST-2 Expression Modulates Small CD4-Mimetic Sensitization of HIV-1-Infected Cells to Antibody-Dependent Cellular Cytotoxicity.
Richard J, Prévost J, von Bredow B, Ding S, Brassard N, Medjahed H, Coutu M, Melillo B, Bibollet-Ruche F, Hahn BH, Kaufmann DE, Smith AB 3rd, Sodroski J, Sauter D, Kirchhoff F, Gee K, Neil SJ, Evans DT, Finzi A. Richard J, et al. Among authors: prevost j. J Virol. 2017 May 12;91(11):e00219-17. doi: 10.1128/JVI.00219-17. Print 2017 Jun 1. J Virol. 2017. PMID: 28331088 Free PMC article.
Impact of HIV-1 Envelope Conformation on ADCC Responses.
Richard J, Prévost J, Alsahafi N, Ding S, Finzi A. Richard J, et al. Among authors: prevost j. Trends Microbiol. 2018 Apr;26(4):253-265. doi: 10.1016/j.tim.2017.10.007. Epub 2017 Nov 20. Trends Microbiol. 2018. PMID: 29162391 Review.
296 results