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Mixed responses to targeted therapy driven by chromosomal instability through p53 dysfunction and genome doubling.
Hobor S, Al Bakir M, Hiley CT, Skrzypski M, Frankell AM, Bakker B, Watkins TBK, Markovets A, Dry JR, Brown AP, van der Aart J, van den Bos H, Spierings D, Oukrif D, Novelli M, Chakrabarti T, Rabinowitz AH, Ait Hassou L, Litière S, Kerr DL, Tan L, Kelly G, Moore DA, Renshaw MJ, Venkatesan S, Hill W, Huebner A, Martínez-Ruiz C, Black JRM, Wu W, Angelova M, McGranahan N, Downward J, Chmielecki J, Barrett C, Litchfield K, Chew SK, Blakely CM, de Bruin EC, Foijer F, Vousden KH, Bivona TG; TRACERx consortium; Hynds RE, Kanu N, Zaccaria S, Grönroos E, Swanton C. Hobor S, et al. Among authors: van den bos h. Nat Commun. 2024 Jun 13;15(1):4871. doi: 10.1038/s41467-024-47606-9. Nat Commun. 2024. PMID: 38871738 Free PMC article.
Microarray analysis of gene expression profiles in the rat kidney demonstrates a local inflammatory response induced by cardiopulmonary bypass.
Bouma HR, Samarska IV, Schenk M, Dahlem KK, van den Bos H, Brebenel I, Duin M, Houwertjes MC, Loef BG, Mungroop HE, Struys MM, Epema AH, Henning RH. Bouma HR, et al. Among authors: van den bos h. Eur J Anaesthesiol. 2013 Aug;30(8):492-500. doi: 10.1097/EJA.0b013e32835ce530. Eur J Anaesthesiol. 2013. PMID: 23344121
Single-cell whole genome sequencing reveals no evidence for common aneuploidy in normal and Alzheimer's disease neurons.
van den Bos H, Spierings DC, Taudt AS, Bakker B, Porubský D, Falconer E, Novoa C, Halsema N, Kazemier HG, Hoekstra-Wakker K, Guryev V, den Dunnen WF, Foijer F, Tatché MC, Boddeke HW, Lansdorp PM. van den Bos H, et al. Among authors: den dunnen wf. Genome Biol. 2016 May 31;17(1):116. doi: 10.1186/s13059-016-0976-2. Genome Biol. 2016. PMID: 27246599 Free PMC article.
Copy number alterations assessed at the single-cell level revealed mono- and polyclonal seeding patterns of distant metastasis in a small-cell lung cancer patient.
Ferronika P, van den Bos H, Taudt A, Spierings DCJ, Saber A, Hiltermann TJN, Kok K, Porubsky D, van der Wekken AJ, Timens W, Foijer F, Colomé-Tatché M, Groen HJM, Lansdorp PM, van den Berg A. Ferronika P, et al. Among authors: van der wekken aj, van den bos h, van den berg a. Ann Oncol. 2017 Jul 1;28(7):1668-1670. doi: 10.1093/annonc/mdx182. Ann Oncol. 2017. PMID: 28419234 Free article. No abstract available.
Single-cell sequencing to quantify genomic integrity in cancer.
van den Bos H, Bakker B, Spierings DCJ, Lansdorp PM, Foijer F. van den Bos H, et al. Int J Biochem Cell Biol. 2018 Jan;94:146-150. doi: 10.1016/j.biocel.2017.09.016. Epub 2017 Sep 23. Int J Biochem Cell Biol. 2018. PMID: 28951245 Review.
Quantification of Aneuploidy in Mammalian Systems.
van den Bos H, Bakker B, Taudt A, Guryev V, Colomé-Tatché M, Lansdorp PM, Foijer F, Spierings DCJ. van den Bos H, et al. Methods Mol Biol. 2019;1896:159-190. doi: 10.1007/978-1-4939-8931-7_15. Methods Mol Biol. 2019. PMID: 30474848
PIDDosome-induced p53-dependent ploidy restriction facilitates hepatocarcinogenesis.
Sladky VC, Knapp K, Szabo TG, Braun VZ, Bongiovanni L, van den Bos H, Spierings DC, Westendorp B, Curinha A, Stojakovic T, Scharnagl H, Timelthaler G, Tsuchia K, Pinter M, Semmler G, Foijer F, de Bruin A, Reiberger T, Rohr-Udilova N, Villunger A. Sladky VC, et al. Among authors: van den bos h. EMBO Rep. 2020 Dec 3;21(12):e50893. doi: 10.15252/embr.202050893. Epub 2020 Nov 23. EMBO Rep. 2020. PMID: 33225610 Free PMC article.
The H3.3K27M oncohistone affects replication stress outcome and provokes genomic instability in pediatric glioma.
Bočkaj I, Martini TEI, de Camargo Magalhães ES, Bakker PL, Meeuwsen-de Boer TGJ, Armandari I, Meuleman SL, Mondria MT, Stok C, Kok YP, Bakker B, Wardenaar R, Seiler J, Broekhuis MJC, van den Bos H, Spierings DCJ, Ringnalda FCA, Clevers H, Schüller U, van Vugt MATM, Foijer F, Bruggeman SWM. Bočkaj I, et al. Among authors: van den bos h. PLoS Genet. 2021 Nov 9;17(11):e1009868. doi: 10.1371/journal.pgen.1009868. eCollection 2021 Nov. PLoS Genet. 2021. PMID: 34752469 Free PMC article.
25 results