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A Prostatic Intraepithelial Neoplasia-Dependent p27Kip1 Checkpoint Induces Senescence and Inhibits Cell Proliferation and Cancer Progression.
Majumder PK, Grisanzio C, O'Connell F, Barry M, Brito JM, Xu Q, Guney I, Berger R, Herman P, Bikoff R, Fedele G, Baek WK, Wang S, Ellwood-Yen K, Wu H, Sawyers CL, Signoretti S, Hahn WC, Loda M, Sellers WR. Majumder PK, et al. Among authors: hahn wc. Cancer Cell. 2024 Jun 10;42(6):1126. doi: 10.1016/j.ccell.2024.05.008. Epub 2024 May 30. Cancer Cell. 2024. PMID: 38866454 No abstract available.
Comprehensive structure-function analysis reveals gain- and loss-of-function mechanisms impacting oncogenic KRAS activity.
Kwon JJ, Dilly J, Liu S, Kim E, Bian Y, Dharmaiah S, Tran TH, Kapner KS, Ly SH, Yang X, Rabara D, Waybright TJ, Giacomelli AO, Hong AL, Misek S, Wang B, Ravi A, Doench JG, Beroukhim R, Lemke CT, Haigis KM, Esposito D, Root DE, Nissley DV, Stephen AG, McCormick F, Simanshu DK, Hahn WC, Aguirre AJ. Kwon JJ, et al. Among authors: hahn wc. bioRxiv [Preprint]. 2024 Oct 25:2024.10.22.618529. doi: 10.1101/2024.10.22.618529. bioRxiv. 2024. PMID: 39484452 Free PMC article. Preprint.
The present and future of the Cancer Dependency Map.
Arafeh R, Shibue T, Dempster JM, Hahn WC, Vazquez F. Arafeh R, et al. Among authors: hahn wc. Nat Rev Cancer. 2025 Jan;25(1):59-73. doi: 10.1038/s41568-024-00763-x. Epub 2024 Oct 28. Nat Rev Cancer. 2025. PMID: 39468210 Review.
Scalable, compressed phenotypic screening using pooled perturbations.
Liu N, Kattan WE, Mead BE, Kummerlowe C, Cheng T, Ingabire S, Cheah JH, Soule CK, Vrcic A, McIninch JK, Triana S, Guzman M, Dao TT, Peters JM, Lowder KE, Crawford L, Amini AP, Blainey PC, Hahn WC, Cleary B, Bryson B, Winter PS, Raghavan S, Shalek AK. Liu N, et al. Among authors: hahn wc. Nat Biotechnol. 2024 Oct 7. doi: 10.1038/s41587-024-02403-z. Online ahead of print. Nat Biotechnol. 2024. PMID: 39375446
377 results