Orkin SH - Search Results

1

Mechanistic and kinetic insights into transcription factor biology via acute protein depletion.

Mehta S, Buyanbat A, Kai Y, Orkin SH. Mehta S, et al. Among authors: orkin sh. Exp Hematol. 2024 Sep;137:104250. doi: 10.1016/j.exphem.2024.104250. Epub 2024 Jun 9. Exp Hematol. 2024. PMID: 38862078 Free article. Review.

2

High-efficiency knock-in of degradable tags (dTAG) at endogenous loci in cell lines.

Mehta S, Buyanbat A, Orkin S, Nabet B. Mehta S, et al. Methods Enzymol. 2023;681:1-22. doi: 10.1016/bs.mie.2022.08.045. Epub 2022 Nov 30. Methods Enzymol. 2023. PMID: 36764753

3

Leukemia core transcriptional circuitry is a sparsely interconnected hierarchy stabilized by incoherent feed-forward loops.

Harada T, Kalfon J, Perez MW, Eagle K, Braes FD, Batley R, Heshmati Y, Ferrucio JX, Ewers J, Mehta S, Kossenkov A, Ellegast JM, Bowker A, Wickramasinghe J, Nabet B, Paralkar VR, Dharia NV, Stegmaier K, Orkin SH, Pimkin M. Harada T, et al. Among authors: orkin sh. bioRxiv [Preprint]. 2023 Mar 15:2023.03.13.532438. doi: 10.1101/2023.03.13.532438. bioRxiv. 2023. PMID: 36993171 Free PMC article. Preprint.

4

Identifying Quantitatively Differential Chromosomal Compartmentalization Changes and Their Biological Significance from Hi-C data using DARIC.

Kai Y, Liu N, Orkin SH, Yuan GC. Kai Y, et al. Among authors: orkin sh. Res Sq [Preprint]. 2023 Apr 28:rs.3.rs-2814806. doi: 10.21203/rs.3.rs-2814806/v1. Res Sq. 2023. Update in: BMC Genomics. 2023 Oct 13;24(1):614. doi: 10.1186/s12864-023-09675-w PMID: 37162846 Free PMC article. Updated. Preprint.

5

Identifying quantitatively differential chromosomal compartmentalization changes and their biological significance from Hi-C data using DARIC.

Kai Y, Liu N, Orkin SH, Yuan GC. Kai Y, et al. Among authors: orkin sh. BMC Genomics. 2023 Oct 13;24(1):614. doi: 10.1186/s12864-023-09675-w. BMC Genomics. 2023. PMID: 37833630 Free PMC article.

6

Fetal Hemoglobin Regulation in Beta-Thalassemia.

Lu HY, Orkin SH, Sankaran VG. Lu HY, et al. Among authors: orkin sh. Hematol Oncol Clin North Am. 2023 Apr;37(2):301-312. doi: 10.1016/j.hoc.2022.12.002. Hematol Oncol Clin North Am. 2023. PMID: 36907604 Review.

7

Transcriptional Repressor BCL11A in Erythroid Cells.

Zheng G, Orkin SH. Zheng G, et al. Among authors: orkin sh. Adv Exp Med Biol. 2024;1459:199-215. doi: 10.1007/978-3-031-62731-6_9. Adv Exp Med Biol. 2024. PMID: 39017845 Review.

8

Structural insights into the DNA-binding mechanism of BCL11A: The integral role of ZnF6.

Viennet T, Yin M, Jayaraj A, Kim W, Sun ZJ, Fujiwara Y, Zhang K, Seruggia D, Seo HS, Dhe-Paganon S, Orkin SH, Arthanari H. Viennet T, et al. Among authors: orkin sh. Structure. 2024 Dec 5;32(12):2276-2286.e4. doi: 10.1016/j.str.2024.09.022. Epub 2024 Oct 17. Structure. 2024. PMID: 39423807

9

Redirecting E3 Ubiquitin Ligases for Targeted Protein Degradation with Heterologous Recognition Domains.

Yang H, Zheng G, Li GY, Alshaye A, Orkin SH. Yang H, et al. Among authors: orkin sh. J Biol Chem. 2024 Dec 13:108077. doi: 10.1016/j.jbc.2024.108077. Online ahead of print. J Biol Chem. 2024. PMID: 39675716 Free article.

10

A Cell-Permeant Nanobody-Based Degrader That Induces Fetal Hemoglobin.

Shen F, Zheng G, Setegne M, Tenglin K, Izadi M, Xie H, Zhai L, Orkin SH, Dassama LMK. Shen F, et al. Among authors: orkin sh. ACS Cent Sci. 2022 Dec 28;8(12):1695-1703. doi: 10.1021/acscentsci.2c00998. Epub 2022 Dec 14. ACS Cent Sci. 2022. PMID: 36589886 Free PMC article.

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