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Next generation risk assessment for occupational chemical safety - A real world example with sodium-2-hydroxyethane sulfonate.
Wood A, Breffa C, Chaine C, Cubberley R, Dent M, Eichhorn J, Fayyaz S, Grimm FA, Houghton J, Kiwamoto R, Kukic P, Lee M, Malcomber S, Martin S, Nicol B, Reynolds J, Riley G, Scott S, Smith C, Westmoreland C, Wieland W, Williams M, Wolton K, Zellmann T, Gutsell S. Wood A, et al. Among authors: nicol b. Toxicology. 2024 Aug;506:153835. doi: 10.1016/j.tox.2024.153835. Epub 2024 Jun 8. Toxicology. 2024. PMID: 38857863 Free article.
Implementing Toxicity Testing in the 21st Century (TT21C): Making safety decisions using toxicity pathways, and progress in a prototype risk assessment.
Adeleye Y, Andersen M, Clewell R, Davies M, Dent M, Edwards S, Fowler P, Malcomber S, Nicol B, Scott A, Scott S, Sun B, Westmoreland C, White A, Zhang Q, Carmichael PL. Adeleye Y, et al. Among authors: nicol b. Toxicology. 2015 Jun 5;332:102-11. doi: 10.1016/j.tox.2014.02.007. Epub 2014 Feb 25. Toxicology. 2015. PMID: 24582757 Free article.
A Next-Generation Risk Assessment Case Study for Coumarin in Cosmetic Products.
Baltazar MT, Cable S, Carmichael PL, Cubberley R, Cull T, Delagrange M, Dent MP, Hatherell S, Houghton J, Kukic P, Li H, Lee MY, Malcomber S, Middleton AM, Moxon TE, Nathanail AV, Nicol B, Pendlington R, Reynolds G, Reynolds J, White A, Westmoreland C. Baltazar MT, et al. Among authors: nicol b. Toxicol Sci. 2020 Jul 1;176(1):236-252. doi: 10.1093/toxsci/kfaa048. Toxicol Sci. 2020. PMID: 32275751 Free PMC article.
Next generation risk assessment (NGRA): Bridging in vitro points-of-departure to human safety assessment using physiologically-based kinetic (PBK) modelling - A case study of doxorubicin with dose metrics considerations.
Li H, Yuan H, Middleton A, Li J, Nicol B, Carmichael P, Guo J, Peng S, Zhang Q. Li H, et al. Among authors: nicol b. Toxicol In Vitro. 2021 Aug;74:105171. doi: 10.1016/j.tiv.2021.105171. Epub 2021 Apr 20. Toxicol In Vitro. 2021. PMID: 33848589
Are Non-animal Systemic Safety Assessments Protective? A Toolbox and Workflow.
Middleton AM, Reynolds J, Cable S, Baltazar MT, Li H, Bevan S, Carmichael PL, Dent MP, Hatherell S, Houghton J, Kukic P, Liddell M, Malcomber S, Nicol B, Park B, Patel H, Scott S, Sparham C, Walker P, White A. Middleton AM, et al. Among authors: nicol b. Toxicol Sci. 2022 Aug 25;189(1):124-147. doi: 10.1093/toxsci/kfac068. Toxicol Sci. 2022. PMID: 35822611 Free PMC article.
In vitro to in vivo extrapolation to derive a metabolism factor for estimating the aggregate exposure to salicylic acid after dermal exposure of its esters.
Najjar A, Grégoire S, Nicol B, Natsch A, Golbamaki N, Boisleve F, Irizar A, Wall B, Swinscoe A, Masini-Etévé V, Selechnik D, Api AM, Griem P, Hewitt N, Cardamone E. Najjar A, et al. Among authors: nicol b. Arch Toxicol. 2024 Jul;98(7):2199-2211. doi: 10.1007/s00204-024-03749-8. Epub 2024 Apr 24. Arch Toxicol. 2024. PMID: 38658404 Free PMC article.
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