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Multi-omic Analysis of Human B-cell Activation Reveals a Key Lysosomal BCAT1 Role in mTOR Hyperactivation by B-cell receptor and TLR9.
Gewurz B, Guo R, Lim M, Shah H, Paulo J, Zhang Y, Yang H, Wang LW, Strebinger D, Smith N, Li M, Leong M, Lutchenkov M, Liang JH, Li Z, Wang Y, Puri R, Melnick A, Green M, Asara J, Papathanassiu A, Gygi S, Mootha V. Gewurz B, et al. Among authors: shah h. Res Sq [Preprint]. 2024 May 30:rs.3.rs-4413958. doi: 10.21203/rs.3.rs-4413958/v1. Res Sq. 2024. PMID: 38854072 Free PMC article. Preprint.
SARS-CoV-2 hijacks folate and one-carbon metabolism for viral replication.
Zhang Y, Guo R, Kim SH, Shah H, Zhang S, Liang JH, Fang Y, Gentili M, Leary CNO, Elledge SJ, Hung DT, Mootha VK, Gewurz BE. Zhang Y, et al. Among authors: shah h. Nat Commun. 2021 Mar 15;12(1):1676. doi: 10.1038/s41467-021-21903-z. Nat Commun. 2021. PMID: 33723254 Free PMC article.
Insulin Sensitivity and Insulin Secretion in Adults With Friedreich's Ataxia: The Role of Skeletal Muscle.
Tamaroff J, Nguyen S, Wilson NE, Stefanovski D, Xiao R, Scattergood T, Capiola C, Schur GM, Dunn J, Dedio A, Wade K, Shah H, Sharma R, Mootha VK, Kelly A, Lin KY, Lynch DR, Reddy R, Rickels MR, McCormack SE. Tamaroff J, et al. Among authors: shah h. J Clin Endocrinol Metab. 2025 Jan 21;110(2):317-333. doi: 10.1210/clinem/dgae545. J Clin Endocrinol Metab. 2025. PMID: 39109797 Free PMC article.
Congenital Hypermetabolism and Uncoupled Oxidative Phosphorylation.
Ganetzky RD, Markhard AL, Yee I, Clever S, Cahill A, Shah H, Grabarek Z, To TL, Mootha VK. Ganetzky RD, et al. Among authors: shah h. N Engl J Med. 2022 Oct 13;387(15):1395-1403. doi: 10.1056/NEJMoa2202949. N Engl J Med. 2022. PMID: 36239646 Free PMC article.
Hepatic NADH reductive stress underlies common variation in metabolic traits.
Goodman RP, Markhard AL, Shah H, Sharma R, Skinner OS, Clish CB, Deik A, Patgiri A, Hsu YH, Masia R, Noh HL, Suk S, Goldberger O, Hirschhorn JN, Yellen G, Kim JK, Mootha VK. Goodman RP, et al. Among authors: shah h. Nature. 2020 Jul;583(7814):122-126. doi: 10.1038/s41586-020-2337-2. Epub 2020 May 27. Nature. 2020. PMID: 32461692 Free PMC article.
2,571 results