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Multi-omic Analysis of Human B-cell Activation Reveals a Key Lysosomal BCAT1 Role in mTOR Hyperactivation by B-cell receptor and TLR9.
Gewurz B, Guo R, Lim M, Shah H, Paulo J, Zhang Y, Yang H, Wang LW, Strebinger D, Smith N, Li M, Leong M, Lutchenkov M, Liang JH, Li Z, Wang Y, Puri R, Melnick A, Green M, Asara J, Papathanassiu A, Gygi S, Mootha V. Gewurz B, et al. Among authors: mootha v. Res Sq [Preprint]. 2024 May 30:rs.3.rs-4413958. doi: 10.21203/rs.3.rs-4413958/v1. Res Sq. 2024. PMID: 38854072 Free PMC article. Preprint.
Epstein-Barr-Virus-Induced One-Carbon Metabolism Drives B Cell Transformation.
Wang LW, Shen H, Nobre L, Ersing I, Paulo JA, Trudeau S, Wang Z, Smith NA, Ma Y, Reinstadler B, Nomburg J, Sommermann T, Cahir-McFarland E, Gygi SP, Mootha VK, Weekes MP, Gewurz BE. Wang LW, et al. Cell Metab. 2019 Sep 3;30(3):539-555.e11. doi: 10.1016/j.cmet.2019.06.003. Epub 2019 Jun 27. Cell Metab. 2019. PMID: 31257153 Free PMC article.
Congenital Hypermetabolism and Uncoupled Oxidative Phosphorylation.
Ganetzky RD, Markhard AL, Yee I, Clever S, Cahill A, Shah H, Grabarek Z, To TL, Mootha VK. Ganetzky RD, et al. N Engl J Med. 2022 Oct 13;387(15):1395-1403. doi: 10.1056/NEJMoa2202949. N Engl J Med. 2022. PMID: 36239646 Free PMC article.
Cytosolic N6AMT1-dependent translation supports mitochondrial RNA processing.
Foged MM, Recazens E, Chollet S, Lisci M, Allen GE, Zinshteyn B, Boutguetait D, Münch C, Mootha VK, Jourdain AA. Foged MM, et al. Among authors: mootha vk. Proc Natl Acad Sci U S A. 2024 Nov 19;121(47):e2414187121. doi: 10.1073/pnas.2414187121. Epub 2024 Nov 6. Proc Natl Acad Sci U S A. 2024. PMID: 39503847 Free PMC article.
291 results