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The interaction of the azetidine thiazole side chain with the active site loop (ASL) 3 drives the evolution of IMP metallo-β-lactamase against tebipenem.
Antimicrob Agents Chemother. 2024 Aug 7;68(8):e0068724. doi: 10.1128/aac.00687-24. Epub 2024 Jul 18.
Antimicrob Agents Chemother. 2024.
PMID: 39023262
Development of non-β-Lactam covalent allosteric inhibitors targeting PBP2a in Methicillin-Resistant Staphylococcus aureus.
Benin BM, Kharel R, Hillyer T, Sun C, Cmolik A, Kuebler T, Sham YY, Bonomo R, Mighion JD, Shin WS.
Benin BM, et al. Among authors: cmolik a.
bioRxiv [Preprint]. 2024 May 30:2024.05.29.596450. doi: 10.1101/2024.05.29.596450.
bioRxiv. 2024.
PMID: 38853829
Free PMC article.
Preprint.
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Characterization of a Novel Pathogen in Immunocompromised Patients: Elizabethkingia anophelis-Exploring the Scope of Resistance to Contemporary Antimicrobial Agents and β-lactamase Inhibitors.
Yasmin M, Rojas LJ, Marshall SH, Hujer AM, Cmolik A, Marshall E, Boucher HW, Vila AJ, Soldevila M, Diene SM, Rolain JM, Bonomo RA.
Yasmin M, et al. Among authors: cmolik a.
Open Forum Infect Dis. 2023 Jan 31;10(2):ofad014. doi: 10.1093/ofid/ofad014. eCollection 2023 Feb.
Open Forum Infect Dis. 2023.
PMID: 36820316
Free PMC article.
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A γ-Lactam Siderophore Antibiotic Effective against Multidrug-Resistant Gram-Negative Bacilli.
Goldberg JA, Nguyen H, Kumar V, Spencer EJ, Hoyer D, Marshall EK, Cmolik A, O'Shea M, Marshall SH, Hujer AM, Hujer KM, Rudin SD, Domitrovic TN, Bethel CR, Papp-Wallace KM, Logan LK, Perez F, Jacobs MR, van Duin D, Kreiswirth BM, Bonomo RA, Plummer MS, van den Akker F.
Goldberg JA, et al. Among authors: cmolik a.
J Med Chem. 2020 Jun 11;63(11):5990-6002. doi: 10.1021/acs.jmedchem.0c00255. Epub 2020 Jun 2.
J Med Chem. 2020.
PMID: 32420736
Free PMC article.
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