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Page 1
The challenge to identify sensitive safety biomarkers of peripheral neurotoxicity in the rat: A collaborative effort across industry and academia (IMI NeuroDeRisk project).
Micheli L, Balayssac D, Busserolles J, Dalbos C, Prival L, Richard D, Quintana M, Di Cesare Mannelli L, Toti A, Ciampi C, Ghelardini C, Vlasakova K, Glaab WE, Hu Y, Loryan I, Perrault O, Slaoui M, Wuersch K, Johnson E, Frieauff W, Penraat K, Brees D, Dubost V, Theil D. Micheli L, et al. Among authors: prival l. Toxicology. 2025 Jan;510:153998. doi: 10.1016/j.tox.2024.153998. Epub 2024 Nov 17. Toxicology. 2025. PMID: 39551123 Free article.
The TREK-1 potassium channel is involved in both the analgesic and anti-proliferative effects of riluzole in bone cancer pain.
Delanne-Cuménal M, Lamoine S, Meleine M, Aissouni Y, Prival L, Fereyrolles M, Barbier J, Cercy C, Boudieu L, Schopp J, Lazdunski M, Eschalier A, Lolignier S, Busserolles J. Delanne-Cuménal M, et al. Among authors: prival l. Biomed Pharmacother. 2024 Jul;176:116887. doi: 10.1016/j.biopha.2024.116887. Epub 2024 Jun 8. Biomed Pharmacother. 2024. PMID: 38852511 Free article.
Neurofilament light chain in plasma as a sensitive diagnostic biomarker of peripheral neurotoxicity: In Vivo mouse studies with oxaliplatin and paclitaxel - NeuroDeRisk project.
Balayssac D, Busserolles J, Broto C, Dalbos C, Prival L, Lamoine S, Richard D, Quintana M, Herbet A, Hilairet S, Hu Y, Loryan I, Glaab WE, Micheli L, Ghelardini C, Di Cesare Mannelli L, Perrault O, Slaoui M. Balayssac D, et al. Among authors: prival l. Biomed Pharmacother. 2023 Nov;167:115535. doi: 10.1016/j.biopha.2023.115535. Epub 2023 Sep 20. Biomed Pharmacother. 2023. PMID: 37738793 Free article.
The Class I HDAC Inhibitor, MS-275, Prevents Oxaliplatin-Induced Chronic Neuropathy and Potentiates Its Antiproliferative Activity in Mice.
Lamoine S, Cumenal M, Barriere DA, Pereira V, Fereyrolles M, Prival L, Barbier J, Boudieu L, Brasset E, Bertin B, Renaud Y, Miot-Noirault E, Civiale MA, Balayssac D, Aissouni Y, Eschalier A, Busserolles J. Lamoine S, et al. Among authors: prival l. Int J Mol Sci. 2021 Dec 22;23(1):98. doi: 10.3390/ijms23010098. Int J Mol Sci. 2021. PMID: 35008525 Free PMC article.
Testosterone-androgen receptor: The steroid link inhibiting TRPM8-mediated cold sensitivity.
Gkika D, Lolignier S, Grolez GP, Bavencoffe A, Shapovalov G, Gordienko D, Kondratskyi A, Meleine M, Prival L, Chapuy E, Etienne M, Eschalier A, Shuba Y, Skryma R, Busserolles J, Prevarskaya N. Gkika D, et al. Among authors: prival l. FASEB J. 2020 Jun;34(6):7483-7499. doi: 10.1096/fj.201902270R. Epub 2020 Apr 11. FASEB J. 2020. PMID: 32277850
Targeting the TREK-1 potassium channel via riluzole to eliminate the neuropathic and depressive-like effects of oxaliplatin.
Poupon L, Lamoine S, Pereira V, Barriere DA, Lolignier S, Giraudet F, Aissouni Y, Meleine M, Prival L, Richard D, Kerckhove N, Authier N, Balayssac D, Eschalier A, Lazdunski M, Busserolles J. Poupon L, et al. Among authors: prival l. Neuropharmacology. 2018 Sep 15;140:43-61. doi: 10.1016/j.neuropharm.2018.07.026. Epub 2018 Jul 26. Neuropharmacology. 2018. PMID: 30056126 Free article.
Development of the First Two-Pore Domain Potassium Channel TWIK-Related K+ Channel 1-Selective Agonist Possessing in Vivo Antinociceptive Activity.
Vivier D, Soussia IB, Rodrigues N, Lolignier S, Devilliers M, Chatelain FC, Prival L, Chapuy E, Bourdier G, Bennis K, Lesage F, Eschalier A, Busserolles J, Ducki S. Vivier D, et al. Among authors: prival l. J Med Chem. 2017 Feb 9;60(3):1076-1088. doi: 10.1021/acs.jmedchem.6b01285. Epub 2017 Jan 20. J Med Chem. 2017. PMID: 28051863
The Nav1.9 channel is a key determinant of cold pain sensation and cold allodynia.
Lolignier S, Bonnet C, Gaudioso C, Noël J, Ruel J, Amsalem M, Ferrier J, Rodat-Despoix L, Bouvier V, Aissouni Y, Prival L, Chapuy E, Padilla F, Eschalier A, Delmas P, Busserolles J. Lolignier S, et al. Among authors: prival l. Cell Rep. 2015 May 19;11(7):1067-78. doi: 10.1016/j.celrep.2015.04.027. Epub 2015 May 7. Cell Rep. 2015. PMID: 25959819 Free article.