Kempen AL - Search Results

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Non-kinase off-target inhibitory activities of clinically-relevant kinase inhibitors.

Brauer NR, Kempen AL, Hernandez D, Sintim HO. Brauer NR, et al. Among authors: kempen al. Eur J Med Chem. 2024 Sep 5;275:116540. doi: 10.1016/j.ejmech.2024.116540. Epub 2024 May 31. Eur J Med Chem. 2024. PMID: 38852338 Review.

Discovery of imidazo[1,2-b]pyridazine-containing TAK1 kinase inhibitors with excellent activities against multiple myeloma.

Akwata D, Kempen AL, Lamptey J, Dayal N, Brauer NR, Sintim HO. Akwata D, et al. Among authors: kempen al. RSC Med Chem. 2023 Nov 28;15(1):178-192. doi: 10.1039/d3md00415e. eCollection 2024 Jan 25. RSC Med Chem. 2023. PMID: 38283221 Free PMC article.

Identification of a Selective FLT3 Inhibitor with Low Activity against VEGFR, FGFR, PDGFR, c-KIT, and RET Anti-Targets.

Akwata D, Kempen AL, Dayal N, Brauer NR, Sintim HO. Akwata D, et al. Among authors: kempen al. ChemMedChem. 2024 Jan 2;19(1):e202300442. doi: 10.1002/cmdc.202300442. Epub 2023 Dec 7. ChemMedChem. 2024. PMID: 37971283

Dual FLT3/haspin kinase inhibitor based on 3H-pyrazolo[4,3-f]quinoline scaffold with activities against acute myeloid leukemia.

Kempen AL, Brauer NR, Sintim HO. Kempen AL, et al. RSC Med Chem. 2023 Jul 14;14(9):1743-1754. doi: 10.1039/d3md00192j. eCollection 2023 Sep 19. RSC Med Chem. 2023. PMID: 37731695 Free PMC article.

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