Huang W - Search Results

1

Mechanisms of acquired resistance to HER2-Positive breast cancer therapies induced by HER3: A comprehensive review.

Geng W, Thomas H, Chen Z, Yan Z, Zhang P, Zhang M, Huang W, Ren X, Wang Z, Ding K, Zhang J. Geng W, et al. Among authors: huang w. Eur J Pharmacol. 2024 Aug 15;977:176725. doi: 10.1016/j.ejphar.2024.176725. Epub 2024 Jun 6. Eur J Pharmacol. 2024. PMID: 38851563 Free article. Review.

2

Colorimetric determination of the early biomarker hypoxia-inducible factor-1 alpha (HIF-1α) in circulating exosomes by using a gold seed-coated with aptamer-functionalized Au@Au core-shell peroxidase mimic.

Wang QL, Huang WX, Zhang PJ, Chen L, Lio CK, Zhou H, Qing LS, Luo P. Wang QL, et al. Mikrochim Acta. 2019 Dec 18;187(1):61. doi: 10.1007/s00604-019-4035-z. Mikrochim Acta. 2019. PMID: 31853650

3

Targeting the Non-Catalytic Functions: a New Paradigm for Kinase Drug Discovery?

Wang Z, Huang W, Zhou K, Ren X, Ding K. Wang Z, et al. Among authors: huang w. J Med Chem. 2022 Feb 10;65(3):1735-1748. doi: 10.1021/acs.jmedchem.1c01978. Epub 2022 Jan 9. J Med Chem. 2022. PMID: 35000385

4

A novel photocaged B-Raf^V600E inhibitor toward precise melanoma treatment.

Chen Z, Ke R, Song Z, Zhou Y, Ren X, Huang W, Wang Z, Ding K. Chen Z, et al. Among authors: huang w. Bioorg Med Chem Lett. 2022 May 15;64:128683. doi: 10.1016/j.bmcl.2022.128683. Epub 2022 Mar 17. Bioorg Med Chem Lett. 2022. PMID: 35307569

5

Discovery of a Highly Potent and Selective Dual PROTAC Degrader of CDK12 and CDK13.

Yang J, Chang Y, Tien JC, Wang Z, Zhou Y, Zhang P, Huang W, Vo J, Apel IJ, Wang C, Zeng VZ, Cheng Y, Li S, Wang GX, Chinnaiyan AM, Ding K. Yang J, et al. Among authors: huang w. J Med Chem. 2022 Aug 25;65(16):11066-11083. doi: 10.1021/acs.jmedchem.2c00384. Epub 2022 Aug 8. J Med Chem. 2022. PMID: 35938508 Free PMC article.

6

Discovery of AXL Degraders with Improved Potencies in Triple-Negative Breast Cancer (TNBC) Cells.

He R, Song Z, Bai Y, He S, Huang J, Wang Y, Zhou F, Huang W, Guo J, Wang Z, Tu ZC, Ren X, Zhang Z, Xu J, Ding K. He R, et al. Among authors: huang w, huang j. J Med Chem. 2023 Feb 9;66(3):1873-1891. doi: 10.1021/acs.jmedchem.2c01682. Epub 2023 Jan 25. J Med Chem. 2023. PMID: 36695404

7

Discovery of a First-in-Class Degrader for the Lipid Kinase PIKfyve.

Li C, Qiao Y, Jiang X, Liu L, Zheng Y, Qiu Y, Cheng C, Zhou F, Zhou Y, Huang W, Ren X, Wang Y, Wang Z, Chinnaiyan AM, Ding K. Li C, et al. Among authors: huang w. J Med Chem. 2023 Sep 14;66(17):12432-12445. doi: 10.1021/acs.jmedchem.3c00912. Epub 2023 Aug 21. J Med Chem. 2023. PMID: 37605297 Free PMC article.

8

Neuronal K⁺-Cl^- cotransporter KCC2 as a promising drug target for epilepsy treatment.

McMoneagle E, Zhou J, Zhang S, Huang W, Josiah SS, Ding K, Wang Y, Zhang J. McMoneagle E, et al. Among authors: huang w. Acta Pharmacol Sin. 2024 Jan;45(1):1-22. doi: 10.1038/s41401-023-01149-9. Epub 2023 Sep 13. Acta Pharmacol Sin. 2024. PMID: 37704745 Free PMC article. Review.

9

Discovery and optimization of thieno[3,2-d]pyrimidine derivatives as highly selective inhibitors of cyclin-dependent kinase 7.

Zhang H, Lin G, Jia S, Zhang Y, Wu J, Tao Y, Huang W, Song M, Ding K, Ma D, Fan M. Zhang H, et al. Among authors: huang w. Eur J Med Chem. 2024 Jan 5;263:115955. doi: 10.1016/j.ejmech.2023.115955. Epub 2023 Nov 17. Eur J Med Chem. 2024. PMID: 38000213

10

Discovery of LWY713 as a potent and selective FLT3 PROTAC degrader with in vivo activity against acute myeloid leukemia.

Liu W, Bai Y, Zhou L, Jin J, Zhang M, Wang Y, Lin R, Huang W, Ren X, Ma N, Zhou F, Wang Z, Ding K. Liu W, et al. Among authors: huang w. Eur J Med Chem. 2024 Jan 15;264:115974. doi: 10.1016/j.ejmech.2023.115974. Epub 2023 Nov 19. Eur J Med Chem. 2024. PMID: 38007910

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