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A mild increase in nutrient signaling to mTORC1 in mice leads to parenchymal damage, myeloid inflammation and shortened lifespan.
Ortega-Molina A, Lebrero-Fernández C, Sanz A, Calvo-Rubio M, Deleyto-Seldas N, de Prado-Rivas L, Plata-Gómez AB, Fernández-Florido E, González-García P, Vivas-García Y, Sánchez García E, Graña-Castro O, Price NL, Aroca-Crevillén A, Caleiras E, Monleón D, Borrás C, Casanova-Acebes M, de Cabo R, Efeyan A. Ortega-Molina A, et al. Among authors: fernandez florido e. Nat Aging. 2024 Aug;4(8):1102-1120. doi: 10.1038/s43587-024-00635-x. Epub 2024 Jun 7. Nat Aging. 2024. PMID: 38849535 Free PMC article.
HAPLN1 potentiates peritoneal metastasis in pancreatic cancer.
Wiedmann L, De Angelis Rigotti F, Vaquero-Siguero N, Donato E, Espinet E, Moll I, Alsina-Sanchis E, Bohnenberger H, Fernandez-Florido E, Mülfarth R, Vacca M, Gerwing J, Conradi LC, Ströbel P, Trumpp A, Mogler C, Fischer A, Rodriguez-Vita J. Wiedmann L, et al. Among authors: fernandez florido e. Nat Commun. 2023 Apr 24;14(1):2353. doi: 10.1038/s41467-023-38064-w. Nat Commun. 2023. PMID: 37095087 Free PMC article.