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Development of an improved blood-stage malaria vaccine targeting the essential RH5-CyRPA-RIPR invasion complex.
Williams BG, King LDW, Pulido D, Quinkert D, Lias AM, Silk SE, Ragotte RJ, Davies H, Barrett JR, McHugh K, Rigby CA, Alanine DGW, Barfod L, Shea MW, Cowley LA, Dabbs RA, Pattinson DJ, Douglas AD, Lyth OR, Illingworth JJ, Jin J, Carnrot C, Kotraiah V, Christen JM, Noe AR, MacGill RS, King CR, Birkett AJ, Soisson LA, Skinner K, Miura K, Long CA, Higgins MK, Draper SJ. Williams BG, et al. Among authors: higgins mk. Nat Commun. 2024 Jun 7;15(1):4857. doi: 10.1038/s41467-024-48721-3. Nat Commun. 2024. PMID: 38849365 Free PMC article.
Chondroitin sulfate A-adhering Plasmodium falciparum-infected erythrocytes express functionally important antibody epitopes shared by multiple variants.
Barfod L, Dobrilovic T, Magistrado P, Khunrae P, Viwami F, Bruun J, Dahlbäck M, Bernasconi NL, Fried M, John D, Duffy PE, Salanti A, Lanzavecchia A, Lim CT, Ndam NT, Higgins MK, Hviid L. Barfod L, et al. Among authors: higgins mk. J Immunol. 2010 Dec 15;185(12):7553-61. doi: 10.4049/jimmunol.1002390. Epub 2010 Nov 15. J Immunol. 2010. PMID: 21078904 Free PMC article.
Production of full-length soluble Plasmodium falciparum RH5 protein vaccine using a Drosophila melanogaster Schneider 2 stable cell line system.
Hjerrild KA, Jin J, Wright KE, Brown RE, Marshall JM, Labbé GM, Silk SE, Cherry CJ, Clemmensen SB, Jørgensen T, Illingworth JJ, Alanine DG, Milne KH, Ashfield R, de Jongh WA, Douglas AD, Higgins MK, Draper SJ. Hjerrild KA, et al. Among authors: higgins mk. Sci Rep. 2016 Jul 26;6:30357. doi: 10.1038/srep30357. Sci Rep. 2016. PMID: 27457156 Free PMC article.
Accelerating the clinical development of protein-based vaccines for malaria by efficient purification using a four amino acid C-terminal 'C-tag'.
Jin J, Hjerrild KA, Silk SE, Brown RE, Labbé GM, Marshall JM, Wright KE, Bezemer S, Clemmensen SB, Biswas S, Li Y, El-Turabi A, Douglas AD, Hermans P, Detmers FJ, de Jongh WA, Higgins MK, Ashfield R, Draper SJ. Jin J, et al. Among authors: higgins mk. Int J Parasitol. 2017 Jun;47(7):435-446. doi: 10.1016/j.ijpara.2016.12.001. Epub 2017 Jan 30. Int J Parasitol. 2017. PMID: 28153778 Free PMC article.
Human vaccination against Plasmodium vivax Duffy-binding protein induces strain-transcending antibodies.
Payne RO, Silk SE, Elias SC, Milne KH, Rawlinson TA, Llewellyn D, Shakri AR, Jin J, Labbé GM, Edwards NJ, Poulton ID, Roberts R, Farid R, Jørgensen T, Alanine DG, de Cassan SC, Higgins MK, Otto TD, McCarthy JS, de Jongh WA, Nicosia A, Moyle S, Hill AV, Berrie E, Chitnis CE, Lawrie AM, Draper SJ. Payne RO, et al. Among authors: higgins mk. JCI Insight. 2017 Jun 15;2(12):e93683. doi: 10.1172/jci.insight.93683. eCollection 2017 Jun 15. JCI Insight. 2017. PMID: 28614791 Free PMC article.
A new site of attack for a malaria vaccine.
Draper SJ, Higgins MK. Draper SJ, et al. Among authors: higgins mk. Nat Med. 2018 Apr 10;24(4):382-383. doi: 10.1038/nm.4533. Nat Med. 2018. PMID: 29634679 No abstract available.
Malaria Vaccines: Recent Advances and New Horizons.
Draper SJ, Sack BK, King CR, Nielsen CM, Rayner JC, Higgins MK, Long CA, Seder RA. Draper SJ, et al. Among authors: higgins mk. Cell Host Microbe. 2018 Jul 11;24(1):43-56. doi: 10.1016/j.chom.2018.06.008. Cell Host Microbe. 2018. PMID: 30001524 Free PMC article. Review.
148 results