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Ketogenic diet administration later in life improves memory by modifying the synaptic cortical proteome via the PKA signaling pathway in aging mice.
Acuña-Catalán D, Shah S, Wehrfritz C, Nomura M, Acevedo A, Olmos C, Quiroz G, Huerta H, Bons J, Ampuero E, Wyneken U, Sanhueza M, Arancibia F, Contreras D, Cárdenas JC, Morales B, Schilling B, Newman JC, González-Billault C. Acuña-Catalán D, et al. Among authors: huerta h. Cell Rep Med. 2024 Jun 18;5(6):101593. doi: 10.1016/j.xcrm.2024.101593. Epub 2024 Jun 5. Cell Rep Med. 2024. PMID: 38843842 Free PMC article.
Unfolded protein response IRE1/XBP1 signaling is required for healthy mammalian brain aging.
Cabral-Miranda F, Tamburini G, Martinez G, Ardiles AO, Medinas DB, Gerakis Y, Hung MD, Vidal R, Fuentealba M, Miedema T, Duran-Aniotz C, Diaz J, Ibaceta-Gonzalez C, Sabusap CM, Bermedo-Garcia F, Mujica P, Adamson S, Vitangcol K, Huerta H, Zhang X, Nakamura T, Sardi SP, Lipton SA, Kennedy BK, Henriquez JP, Cárdenas JC, Plate L, Palacios AG, Hetz C. Cabral-Miranda F, et al. Among authors: huerta h. EMBO J. 2022 Nov 17;41(22):e111952. doi: 10.15252/embj.2022111952. Epub 2022 Oct 31. EMBO J. 2022. PMID: 36314651 Free PMC article.
Necroptosis inhibition counteracts neurodegeneration, memory decline, and key hallmarks of aging, promoting brain rejuvenation.
Arrázola MS, Lira M, Véliz-Valverde F, Quiroz G, Iqbal S, Eaton SL, Lamont DJ, Huerta H, Ureta G, Bernales S, Cárdenas JC, Cerpa W, Wishart TM, Court FA. Arrázola MS, et al. Among authors: huerta h. Aging Cell. 2023 May;22(5):e13814. doi: 10.1111/acel.13814. Epub 2023 Mar 27. Aging Cell. 2023. PMID: 36973898 Free PMC article.
The IP3R inhibitor desmethylxestospongin B reduces tumor cell migration, invasion and metastasis by impairing lysosome acidification and β1-integrin recycling.
Bustos G, Ahumada-Castro U, Silva-Pavez E, Huerta H, Puebla A, Quezada C, Morgado-Cáceres P, Casanova-Canelo C, Smith-Cortinez N, Podunavac M, Oyarce C, Lladser A, Farias P, Lovy A, Molgó J, Torres VA, Zakarian A, Cárdenas JC. Bustos G, et al. Among authors: huerta h. Biochim Biophys Acta Mol Basis Dis. 2025 Jan;1871(1):167557. doi: 10.1016/j.bbadis.2024.167557. Epub 2024 Oct 31. Biochim Biophys Acta Mol Basis Dis. 2025. PMID: 39486657 Free article.
67 results