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Optimizing liver health before and after gene therapy for hemophilia A.
Ragni MV, Mead H, de Jong YP, Kaczmarek R, Leavitt AD, Long B, Nugent DJ, Sabatino DE, Fong S, von Drygalski A, Walsh CE, Luxon BA. Ragni MV, et al. Among authors: de jong yp. Blood Adv. 2024 Oct 8;8(19):5203-5212. doi: 10.1182/bloodadvances.2024013059. Blood Adv. 2024. PMID: 38843379 Free PMC article. Review.
Immune Responses to Viral Gene Therapy Vectors.
Shirley JL, de Jong YP, Terhorst C, Herzog RW. Shirley JL, et al. Among authors: de jong yp. Mol Ther. 2020 Mar 4;28(3):709-722. doi: 10.1016/j.ymthe.2020.01.001. Epub 2020 Jan 10. Mol Ther. 2020. PMID: 31968213 Free PMC article. Review.
IL-15 blockade and rapamycin rescue multifactorial loss of factor VIII from AAV-transduced hepatocytes in hemophilia A mice.
Butterfield JSS, Yamada K, Bertolini TB, Syed F, Kumar SRP, Li X, Arisa S, Piñeros AR, Tapia A, Rogers CA, Li N, Rana J, Biswas M, Terhorst C, Kaufman RJ, de Jong YP, Herzog RW. Butterfield JSS, et al. Among authors: de jong yp. Mol Ther. 2022 Dec 7;30(12):3552-3569. doi: 10.1016/j.ymthe.2022.07.005. Epub 2022 Jul 12. Mol Ther. 2022. PMID: 35821634 Free PMC article.
Ectopic clotting factor VIII expression and misfolding in hepatocytes as a cause for hepatocellular carcinoma.
Kapelanski-Lamoureux A, Chen Z, Gao ZH, Deng R, Lazaris A, Lebeaupin C, Giles L, Malhotra J, Yong J, Zou C, de Jong YP, Metrakos P, Herzog RW, Kaufman RJ. Kapelanski-Lamoureux A, et al. Among authors: de jong yp. Mol Ther. 2022 Dec 7;30(12):3542-3551. doi: 10.1016/j.ymthe.2022.10.004. Epub 2022 Oct 14. Mol Ther. 2022. PMID: 36242517 Free PMC article.
Experimental Variables that Affect Human Hepatocyte AAV Transduction in Liver Chimeric Mice.
Zou C, Vercauteren KOA, Michailidis E, Kabbani M, Zoluthkin I, Quirk C, Chiriboga L, Yazicioglu M, Anguela XM, Meuleman P, High KA, Herzog RW, de Jong YP. Zou C, et al. Among authors: de jong yp. Mol Ther Methods Clin Dev. 2020 Jun 2;18:189-198. doi: 10.1016/j.omtm.2020.05.033. eCollection 2020 Sep 11. Mol Ther Methods Clin Dev. 2020. PMID: 32637450 Free PMC article.
An RNA-based system to study hepatitis B virus replication and evaluate antivirals.
Yu Y, Schneider WM, Kass MA, Michailidis E, Acevedo A, Pamplona Mosimann AL, Bordignon J, Koenig A, Livingston CM, van Gijzel H, Ni Y, Ambrose PM, Freije CA, Zhang M, Zou C, Kabbani M, Quirk C, Jahan C, Wu X, Urban S, You S, Shlomai A, de Jong YP, Rice CM. Yu Y, et al. Among authors: de jong yp. Sci Adv. 2023 Apr 14;9(15):eadg6265. doi: 10.1126/sciadv.adg6265. Epub 2023 Apr 12. Sci Adv. 2023. PMID: 37043562 Free PMC article.
Superior In vivo Transduction of Human Hepatocytes Using Engineered AAV3 Capsid.
Vercauteren K, Hoffman BE, Zolotukhin I, Keeler GD, Xiao JW, Basner-Tschakarjan E, High KA, Ertl HC, Rice CM, Srivastava A, de Jong YP, Herzog RW. Vercauteren K, et al. Among authors: de jong yp. Mol Ther. 2016 Jun;24(6):1042-1049. doi: 10.1038/mt.2016.61. Epub 2016 Mar 29. Mol Ther. 2016. PMID: 27019999 Free PMC article.
75 results