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Lead optimisation of OXS007417: in vivo PK profile and hERG liability modulation to optimise a small molecule differentiation agent for the potential treatment of acute myeloid leukaemia.
Cogswell TJ, Josa-Culleré L, Zimmer D, Galan SRG, Jay-Smith M, Harris KS, Bataille CJR, Jackson TR, Zhang D, Davies SG, Vyas P, Milne TA, Wynne GM, Russell AJ. Cogswell TJ, et al. Among authors: zimmer d. RSC Med Chem. 2024 Jul 22;15(10):3495-506. doi: 10.1039/d4md00275j. Online ahead of print. RSC Med Chem. 2024. PMID: 39220761 Free PMC article.
Traumatic Brain Injury as an Independent Predictor of Futility in the Early Resuscitation of Patients in Hemorrhagic Shock.
Al-Fadhl MD, Karam MN, Chen J, Zackariya SK, Lain MC, Bales JR, Higgins AB, Laing JT, Wang HS, Andrews MG, Thomas AV, Smith L, Fox MD, Zackariya SK, Thomas SJ, Tincher AM, Al-Fadhl HD, Weston M, Marsh PL, Khan HA, Thomas EJ, Miller JB, Bailey JA, Koenig JJ, Waxman DA, Srikureja D, Fulkerson DH, Fox S, Bingaman G, Zimmer DF, Thompson MA, Bunch CM, Walsh MM; Futile Indicators for Stopping Transfusion in Trauma (FISTT) Collaborative Group. Al-Fadhl MD, et al. Among authors: zimmer df. J Clin Med. 2024 Jul 3;13(13):3915. doi: 10.3390/jcm13133915. J Clin Med. 2024. PMID: 38999481 Free PMC article. Review.
Generation of nanobodies from transgenic 'LamaMice' lacking an endogenous immunoglobulin repertoire.
Eden T, Schaffrath AZ, Wesolowski J, Stähler T, Tode N, Richter N, Schäfer W, Hambach J, Hermans-Borgmeyer I, Woens J, Le Gall CM, Wendler S, Linke-Winnebeck C, Stobbe M, Budnicki I, Wanney A, Heitz Y, Schimmelpfennig L, Schweitzer L, Zimmer D, Stahl E, Seyfried F, Gebhardt AJ, Dieckow L, Riecken K, Fehse B, Bannas P, Magnus T, Verdoes M, Figdor CG, Hartlepp KF, Schleer H, Füner J, Tomas NM, Haag F, Rissiek B, Mann AM, Menzel S, Koch-Nolte F. Eden T, et al. Among authors: zimmer d. Nat Commun. 2024 Jun 3;15(1):4728. doi: 10.1038/s41467-024-48735-x. Nat Commun. 2024. PMID: 38830864 Free PMC article.
A prognostic neural epigenetic signature in high-grade glioma.
Drexler R, Khatri R, Sauvigny T, Mohme M, Maire CL, Ryba A, Zghaibeh Y, Dührsen L, Salviano-Silva A, Lamszus K, Westphal M, Gempt J, Wefers AK, Neumann JE, Bode H, Hausmann F, Huber TB, Bonn S, Jütten K, Delev D, Weber KJ, Harter PN, Onken J, Vajkoczy P, Capper D, Wiestler B, Weller M, Snijder B, Buck A, Weiss T, Göller PC, Sahm F, Menstel JA, Zimmer DN, Keough MB, Ni L, Monje M, Silverbush D, Hovestadt V, Suvà ML, Krishna S, Hervey-Jumper SL, Schüller U, Heiland DH, Hänzelmann S, Ricklefs FL. Drexler R, et al. Among authors: zimmer dn. Nat Med. 2024 Jun;30(6):1622-1635. doi: 10.1038/s41591-024-02969-w. Epub 2024 May 17. Nat Med. 2024. PMID: 38760585 Free PMC article.
260 results