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Spatial regulation by multiple Gremlin1 enhancers provides digit development with cis-regulatory robustness and evolutionary plasticity.
Malkmus J, Ramos Martins L, Jhanwar S, Kircher B, Palacio V, Sheth R, Leal F, Duchesne A, Lopez-Rios J, Peterson KA, Reinhardt R, Onimaru K, Cohn MJ, Zuniga A, Zeller R. Malkmus J, et al. Among authors: sheth r. Nat Commun. 2021 Sep 21;12(1):5557. doi: 10.1038/s41467-021-25810-1. Nat Commun. 2021. PMID: 34548488 Free PMC article.
The formation of the thumb requires direct modulation of Gli3 transcription by Hoxa13.
Bastida MF, Pérez-Gómez R, Trofka A, Zhu J, Rada-Iglesias A, Sheth R, Stadler HS, Mackem S, Ros MA. Bastida MF, et al. Among authors: sheth r. Proc Natl Acad Sci U S A. 2020 Jan 14;117(2):1090-1096. doi: 10.1073/pnas.1919470117. Epub 2020 Jan 2. Proc Natl Acad Sci U S A. 2020. PMID: 31896583 Free PMC article.
414 results