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Severity of effect considerations regarding the use of mutation as a toxicological endpoint for risk assessment: A report from the 8th International Workshop on Genotoxicity Testing (IWGT).
Parsons BL, Beal MA, Dearfield KL, Douglas GR, Gi M, Gollapudi BB, Heflich RH, Horibata K, Kenyon M, Long AS, Lovell DP, Lynch AM, Myers MB, Pfuhler S, Vespa A, Zeller A, Johnson GE, White PA. Parsons BL, et al. Among authors: beal ma. Environ Mol Mutagen. 2024 Jun 3. doi: 10.1002/em.22599. Online ahead of print. Environ Mol Mutagen. 2024. PMID: 38828778 Review.
Establishing a quantitative framework for regulatory interpretation of genetic toxicity dose-response data: Margin of exposure case study of 48 compounds with both in vivo mutagenicity and carcinogenicity dose-response data.
Chepelev N, Long AS, Beal M, Barton-Maclaren T, Johnson G, Dearfield KL, Roberts DJ, van Benthem J, White P. Chepelev N, et al. Environ Mol Mutagen. 2023 Jan;64(1):4-15. doi: 10.1002/em.22517. Epub 2023 Jan 6. Environ Mol Mutagen. 2023. PMID: 36345771 Free PMC article.
Quantitative in vitro to in vivo extrapolation of genotoxicity data provides protective estimates of in vivo dose.
Beal MA, Audebert M, Barton-Maclaren T, Battaion H, Bemis JC, Cao X, Chen C, Dertinger SD, Froetschl R, Guo X, Johnson G, Hendriks G, Khoury L, Long AS, Pfuhler S, Settivari RS, Wickramasuriya S, White P. Beal MA, et al. Environ Mol Mutagen. 2023 Feb;64(2):105-122. doi: 10.1002/em.22521. Epub 2022 Dec 22. Environ Mol Mutagen. 2023. PMID: 36495195
Interpretation of in vitro concentration-response data for risk assessment and regulatory decision-making: Report from the 2022 IWGT quantitative analysis expert working group meeting.
Beal MA, Chen G, Dearfield KL, Gi M, Gollapudi B, Heflich RH, Horibata K, Long AS, Lovell DP, Parsons BL, Pfuhler S, Wills J, Zeller A, Johnson G, White PA. Beal MA, et al. Environ Mol Mutagen. 2023 Dec 19. doi: 10.1002/em.22582. Online ahead of print. Environ Mol Mutagen. 2023. PMID: 38115239 Review.
In Utero Exposure to Benzo[a]Pyrene Increases Mutation Burden in the Soma and Sperm of Adult Mice.
Meier MJ, O'Brien JM, Beal MA, Allan B, Yauk CL, Marchetti F. Meier MJ, et al. Among authors: beal ma. Environ Health Perspect. 2017 Jan;125(1):82-88. doi: 10.1289/EHP211. Epub 2016 Jul 22. Environ Health Perspect. 2017. PMID: 27448386 Free PMC article.
CONCLUSION: In utero exposure to environmental mutagens contributes to somatic and germline mosaicism, permanently affecting both the genetic health of the F1 and the population gene pool. Citation: Meier MJ, O'Brien JM, Beal MA, Allan B, Yauk CL, Marchetti F. 2017. …
CONCLUSION: In utero exposure to environmental mutagens contributes to somatic and germline mosaicism, permanently affecting both the geneti …
34 results