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Synergistic inhibition of ureolytic activity and growth of Klebsiella pneumoniae in vitro suggests cobinding of fluoride and acetohydroxamic acid at the urease active site and provides a novel strategy to combat ureolytic bacteria.
Svane S, Lyngsie MC, Klitgaard JK, Karring H. Svane S, et al. Among authors: klitgaard jk. Heliyon. 2024 May 14;10(10):e31209. doi: 10.1016/j.heliyon.2024.e31209. eCollection 2024 May 30. Heliyon. 2024. PMID: 38826744 Free PMC article.
Systemic thioridazine in combination with dicloxacillin against early aortic graft infections caused by Staphylococcus aureus in a porcine model: In vivo results do not reproduce the in vitro synergistic activity.
Stenger M, Behr-Rasmussen C, Klein K, Grønnemose RB, Andersen TE, Klitgaard JK, Kolmos HJ, Lindholt JS. Stenger M, et al. Among authors: klitgaard jk. PLoS One. 2017 Mar 9;12(3):e0173362. doi: 10.1371/journal.pone.0173362. eCollection 2017. PLoS One. 2017. PMID: 28278183 Free PMC article.
Insight Into the Anti-staphylococcal Activity of JBC 1847 at Sub-Inhibitory Concentration.
Ronco T, Kappel LH, Aragao MF, Biagi N, Svenningsen S, Christensen JB, Permin A, Saaby L, Holmstrøm K, Klitgaard JK, Sabat AJ, Akkerboom V, Monaco M, Tinelli M, Friedrich AW, Jana B, Olsen RH. Ronco T, et al. Among authors: klitgaard jk. Front Microbiol. 2022 Jan 5;12:786173. doi: 10.3389/fmicb.2021.786173. eCollection 2021. Front Microbiol. 2022. PMID: 35069485 Free PMC article.
Discovery of a Potent Adenine-Benzyltriazolo-Pleuromutilin Conjugate with Pronounced Antibacterial Activity against MRSA.
Heidtmann CV, Voukia F, Hansen LN, Sørensen SH, Urlund B, Nielsen S, Pedersen M, Kelawi N, Andersen BN, Pedersen M, Reinholdt P, Kongsted J, Nielsen CU, Klitgaard JK, Nielsen P. Heidtmann CV, et al. Among authors: klitgaard jk. J Med Chem. 2020 Dec 24;63(24):15693-15708. doi: 10.1021/acs.jmedchem.0c01328. Epub 2020 Dec 16. J Med Chem. 2020. PMID: 33325700
21 results