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Sarbecovirus disease susceptibility is conserved across viral and host models.
Leist SR, Schäfer A, Risemberg EL, Bell TA, Hock P, Zweigart MR, Linnertz CL, Miller DR, Shaw GD, de Villena FPM, Ferris MT, Valdar W, Baric RS. Leist SR, et al. Among authors: valdar w. Virus Res. 2024 Aug;346:199399. doi: 10.1016/j.virusres.2024.199399. Epub 2024 Jun 14. Virus Res. 2024. PMID: 38823688 Free PMC article.
A mutation in Themis contributes to peanut-induced oral anaphylaxis in CC027 mice.
Risemberg EL, Smeekens JM, Cisneros MCC, Hampton BK, Hock P, Linnertz CL, Miller DR, Orgel K, Shaw GD, de Villena FPM, Burks AW, Valdar W, Kulis MD, Ferris MT. Risemberg EL, et al. Among authors: valdar w. bioRxiv [Preprint]. 2023 Sep 13:2023.09.13.557467. doi: 10.1101/2023.09.13.557467. bioRxiv. 2023. Update in: J Allergy Clin Immunol. 2024 Aug;154(2):387-397. doi: 10.1016/j.jaci.2024.03.027 PMID: 37745496 Free PMC article. Updated. Preprint.
A mutation in Themis contributes to anaphylaxis severity following oral peanut challenge in CC027 mice.
Risemberg EL, Smeekens JM, Cruz Cisneros MC, Hampton BK, Hock P, Linnertz CL, Miller DR, Orgel K, Shaw GD, de Villena FPM, Burks AW, Valdar W, Kulis MD, Ferris MT. Risemberg EL, et al. Among authors: valdar w. J Allergy Clin Immunol. 2024 Aug;154(2):387-397. doi: 10.1016/j.jaci.2024.03.027. Epub 2024 Apr 24. J Allergy Clin Immunol. 2024. PMID: 38670234
Early life exposure to vitamin D deficiency impairs molecular mechanisms that regulate liver cholesterol biosynthesis, energy metabolism, inflammation, and detoxification.
Knuth MM, Xue J, Elnagheeb M, Gharaibeh RZ, Schoenrock SA, McRitchie S, Brouwer C, Sumner SJ, Tarantino L, Valdar W, Rector RS, Simon JM, Ideraabdullah F. Knuth MM, et al. Among authors: valdar w. Front Endocrinol (Lausanne). 2024 May 10;15:1335855. doi: 10.3389/fendo.2024.1335855. eCollection 2024. Front Endocrinol (Lausanne). 2024. PMID: 38800476 Free PMC article.
Analysis of strain, sex, and diet-dependent modulation of gut microbiota reveals candidate keystone organisms driving microbial diversity in response to American and ketogenic diets.
Salvador AC, Huda MN, Arends D, Elsaadi AM, Gacasan AC, Brockmann GA, Valdar W, Bennett BJ, Threadgill DW. Salvador AC, et al. Among authors: valdar w. Res Sq [Preprint]. 2023 Feb 2:rs.3.rs-2540322. doi: 10.21203/rs.3.rs-2540322/v1. Res Sq. 2023. Update in: Microbiome. 2023 Oct 3;11(1):220. doi: 10.1186/s40168-023-01588-w PMID: 36778219 Free PMC article. Updated. Preprint.
Genetic Mapping of Multiple Traits Identifies Novel Genes for Adiposity, Lipids, and Insulin Secretory Capacity in Outbred Rats.
Hong-Le T, Crouse WL, Keele GR, Holl K, Seshie O, Tschannen M, Craddock A, Das SK, Szalanczy AM, McDonald B, Grzybowski M, Klotz J, Sharma NK, Geurts AM, Key CC, Hawkins G, Valdar W, Mott R, Solberg Woods LC. Hong-Le T, et al. Among authors: valdar w. Diabetes. 2023 Jan 1;72(1):135-148. doi: 10.2337/db22-0252. Diabetes. 2023. PMID: 36219827 Free PMC article.
A Bayesian model selection approach to mediation analysis.
Crouse WL, Keele GR, Gastonguay MS, Churchill GA, Valdar W. Crouse WL, et al. Among authors: valdar w. PLoS Genet. 2022 May 9;18(5):e1010184. doi: 10.1371/journal.pgen.1010184. eCollection 2022 May. PLoS Genet. 2022. PMID: 35533209 Free PMC article.
Transcriptome-wide analyses of adipose tissue in outbred rats reveal genetic regulatory mechanisms relevant for human obesity.
Crouse WL, Das SK, Le T, Keele G, Holl K, Seshie O, Craddock AL, Sharma NK, Comeau ME, Langefeld CD, Hawkins GA, Mott R, Valdar W, Solberg Woods LC. Crouse WL, et al. Among authors: valdar w. Physiol Genomics. 2022 Jun 1;54(6):206-219. doi: 10.1152/physiolgenomics.00172.2021. Epub 2022 Apr 25. Physiol Genomics. 2022. PMID: 35467982 Free PMC article.
91 results