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Scanning mutagenesis of the voltage-gated sodium channel NaV1.2 using base editing.
Pablo JLB, Cornett SL, Wang LA, Jo S, Brünger T, Budnik N, Hegde M, DeKeyser JM, Thompson CH, Doench JG, Lal D, George AL Jr, Pan JQ. Pablo JLB, et al. Among authors: hegde m. Cell Rep. 2024 Jun 25;43(6):114327. doi: 10.1016/j.celrep.2024.114327. Epub 2024 May 31. Cell Rep. 2024. PMID: 38823014 Free PMC article. No abstract available.
Massively parallel assessment of human variants with base editor screens.
Hanna RE, Hegde M, Fagre CR, DeWeirdt PC, Sangree AK, Szegletes Z, Griffith A, Feeley MN, Sanson KR, Baidi Y, Koblan LW, Liu DR, Neal JT, Doench JG. Hanna RE, et al. Among authors: hegde m. Cell. 2021 Feb 18;184(4):1064-1080.e20. doi: 10.1016/j.cell.2021.01.012. Cell. 2021. PMID: 33606977 Free article.
Scanning mutagenesis of the voltage-gated sodium channel NaV1.2 using base editing.
Pablo JLB, Cornett SL, Wang LA, Jo S, Brünger T, Budnik N, Hegde M, DeKeyser JM, Thompson CH, Doench JG, Lal D, George AL Jr, Pan JQ. Pablo JLB, et al. Among authors: hegde m. Cell Rep. 2023 Jun 27;42(6):112563. doi: 10.1016/j.celrep.2023.112563. Epub 2023 Jun 1. Cell Rep. 2023. PMID: 37267104 Free PMC article.
Optimization of Cas12a for multiplexed genome-scale transcriptional activation.
Griffith AL, Zheng F, McGee AV, Miller NW, Szegletes ZM, Reint G, Gademann F, Nwolah I, Hegde M, Liu YV, Goodale A, Doench JG. Griffith AL, et al. Among authors: hegde m. Cell Genom. 2023 Sep 1;3(9):100387. doi: 10.1016/j.xgen.2023.100387. eCollection 2023 Sep 13. Cell Genom. 2023. PMID: 37719144 Free PMC article.
Optimized libraries for CRISPR-Cas9 genetic screens with multiple modalities.
Sanson KR, Hanna RE, Hegde M, Donovan KF, Strand C, Sullender ME, Vaimberg EW, Goodale A, Root DE, Piccioni F, Doench JG. Sanson KR, et al. Among authors: hegde m. Nat Commun. 2018 Dec 21;9(1):5416. doi: 10.1038/s41467-018-07901-8. Nat Commun. 2018. PMID: 30575746 Free PMC article.
698 results