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Targeting ATP2B1 impairs PI3K/Akt/FOXO signaling and reduces SARS-COV-2 infection and replication.
de Antonellis P, Ferrucci V, Miceli M, Bibbo F, Asadzadeh F, Gorini F, Mattivi A, Boccia A, Russo R, Andolfo I, Lasorsa VA, Cantalupo S, Fusco G, Viscardi M, Brandi S, Cerino P, Monaco V, Choi DR, Cheong JH, Iolascon A, Amente S, Monti M, Fava LL, Capasso M, Kim HY, Zollo M. de Antonellis P, et al. Among authors: fava ll. EMBO Rep. 2024 Jul;25(7):2974-3007. doi: 10.1038/s44319-024-00164-z. Epub 2024 May 30. EMBO Rep. 2024. PMID: 38816514 Free PMC article.
Caspase-2 kills cells with extra centrosomes.
Rizzotto D, Vigorito V, Rieder P, Gallob F, Moretta GM, Soratroi C, Riley JS, Bellutti F, Veli SL, Mattivi A, Lohmüller M, Herzog S, Bornhauser BC, Jacotot ED, Villunger A, Fava LL. Rizzotto D, et al. Among authors: fava ll. Sci Adv. 2024 Nov;10(44):eado6607. doi: 10.1126/sciadv.ado6607. Epub 2024 Oct 30. Sci Adv. 2024. PMID: 39475598 Free PMC article.
Extra centrosomes induce PIDD1-mediated inflammation and immunosurveillance.
Garcia-Carpio I, Braun VZ, Weiler ES, Leone M, Niñerola S, Barco A, Fava LL, Villunger A. Garcia-Carpio I, et al. Among authors: fava ll. EMBO J. 2023 Oct 16;42(20):e113510. doi: 10.15252/embj.2023113510. Epub 2023 Aug 2. EMBO J. 2023. PMID: 37530438 Free PMC article.
Loss-of-Function but Not Gain-of-Function Properties of Mutant TP53 Are Critical for the Proliferation, Survival, and Metastasis of a Broad Range of Cancer Cells.
Wang Z, Burigotto M, Ghetti S, Vaillant F, Tan T, Capaldo BD, Palmieri M, Hirokawa Y, Tai L, Simpson DS, Chang C, Huang AS, Lieschke E, Diepstraten ST, Kaloni D, Riffkin C, Huang DCS, Li Wai Suen CSN, Garnham AL, Gibbs P, Visvader JE, Sieber OM, Herold MJ, Fava LL, Kelly GL, Strasser A. Wang Z, et al. Among authors: fava ll. Cancer Discov. 2024 Feb 8;14(2):362-379. doi: 10.1158/2159-8290.CD-23-0402. Cancer Discov. 2024. PMID: 37877779 Free PMC article.
33 results