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Machine learning models for predicting blood pressure phenotypes by combining multiple polygenic risk scores.
Hrytsenko Y, Shea B, Elgart M, Kurniansyah N, Lyons G, Morrison AC, Carson AP, Haring B, Mitchell BD, Psaty BM, Jaeger BC, Gu CC, Kooperberg C, Levy D, Lloyd-Jones D, Choi E, Brody JA, Smith JA, Rotter JI, Moll M, Fornage M, Simon N, Castaldi P, Casanova R, Chung RH, Kaplan R, Loos RJF, Kardia SLR, Rich SS, Redline S, Kelly T, O'Connor T, Zhao W, Kim W, Guo X, Ida Chen YD; Trans-Omics in Precision Medicine Consortium; Sofer T. Hrytsenko Y, et al. Among authors: elgart m. Sci Rep. 2024 May 30;14(1):12436. doi: 10.1038/s41598-024-62945-9. Sci Rep. 2024. PMID: 38816422 Free PMC article.
Correlations between complex human phenotypes vary by genetic background, gender, and environment.
Elgart M, Goodman MO, Isasi C, Chen H, Morrison AC, de Vries PS, Xu H, Manichaikul AW, Guo X, Franceschini N, Psaty BM, Rich SS, Rotter JI, Lloyd-Jones DM, Fornage M, Correa A, Heard-Costa NL, Vasan RS, Hernandez R, Kaplan RC, Redline S; Trans-Omics for Precision Medicine (TOPMed) Consortium; Sofer T. Elgart M, et al. Cell Rep Med. 2022 Dec 20;3(12):100844. doi: 10.1016/j.xcrm.2022.100844. Epub 2022 Dec 12. Cell Rep Med. 2022. PMID: 36513073 Free PMC article.
Machine learning models for blood pressure phenotypes combining multiple polygenic risk scores.
Hrytsenko Y, Shea B, Elgart M, Kurniansyah N, Lyons G, Morrison AC, Carson AP, Haring B, Mitchel BD, Psaty BM, Jaeger BC, Gu CC, Kooperberg C, Levy D, Lloyd-Jones D, Choi E, Brody JA, Smith JA, Rotter JI, Moll M, Fornage M, Simon N, Castaldi P, Casanova R, Chung RH, Kaplan R, Loos RJF, Kardia SLR, Rich SS, Redline S, Kelly T, O'Connor T, Zhao W, Kim W, Guo X, Der Ida Chen Y; Trans-Omics in Precision Medicine Consortium; Sofer T. Hrytsenko Y, et al. Among authors: elgart m. medRxiv [Preprint]. 2023 Dec 14:2023.12.13.23299909. doi: 10.1101/2023.12.13.23299909. medRxiv. 2023. Update in: Sci Rep. 2024 May 30;14(1):12436. doi: 10.1038/s41598-024-62945-9 PMID: 38168328 Free PMC article. Updated. Preprint.
Genetic associations between sleep traits and cognitive ageing outcomes in the Hispanic Community Health Study/Study of Latinos.
Zhang Y, Elgart M, Granot-Hershkovitz E, Wang H, Tarraf W, Ramos AR, Stickel AM, Zeng D, Garcia TP, Testai FD, Wassertheil-Smoller S, Isasi CR, Daviglus ML, Kaplan R, Fornage M, DeCarli C, Redline S, González HM, Sofer T. Zhang Y, et al. Among authors: elgart m. EBioMedicine. 2023 Jan;87:104393. doi: 10.1016/j.ebiom.2022.104393. Epub 2022 Dec 6. EBioMedicine. 2023. PMID: 36493726 Free PMC article.
A parametric bootstrap approach for computing confidence intervals for genetic correlations with application to genetically-determined protein-protein networks.
Tsai YT, Hrytsenko Y, Elgart M, Tahir U, Chen ZZ, Wilson JG, Gerszten R, Sofer T. Tsai YT, et al. Among authors: elgart m. medRxiv [Preprint]. 2023 Oct 25:2023.10.24.23297474. doi: 10.1101/2023.10.24.23297474. medRxiv. 2023. Update in: HGG Adv. 2024 Jul 18;5(3):100304. doi: 10.1016/j.xhgg.2024.100304 PMID: 37961678 Free PMC article. Updated. Preprint.
Non-linear machine learning models incorporating SNPs and PRS improve polygenic prediction in diverse human populations.
Elgart M, Lyons G, Romero-Brufau S, Kurniansyah N, Brody JA, Guo X, Lin HJ, Raffield L, Gao Y, Chen H, de Vries P, Lloyd-Jones DM, Lange LA, Peloso GM, Fornage M, Rotter JI, Rich SS, Morrison AC, Psaty BM, Levy D, Redline S; NHLBI’s Trans-Omics in Precision Medicine (TOPMed) Consortium; Sofer T. Elgart M, et al. Commun Biol. 2022 Aug 22;5(1):856. doi: 10.1038/s42003-022-03812-z. Commun Biol. 2022. PMID: 35995843 Free PMC article.
71 results