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194 results

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Page 1
Discovery of BMS-986308: A Renal Outer Medullary Potassium Channel Inhibitor for the Treatment of Heart Failure.
Richter JM, Gunaga P, Yadav N, Bora RO, Bhide R, Rajugowda N, Govindrajulu K, Godesi S, Akuthota N, Rao P, Sivaraman A, Panda M, Kaspady M, Gupta A, Mathur A, Levesque PC, Gulia J, Dokania M, Ramarao M, Kole P, Chacko S, Lentz KA, Sivaprasad Lvj S, Thatipamula RP, Sridhar S, Kamble S, Govindrajan A, Soleman SI, Gordon DA, Wexler RR, Priestley ES. Richter JM, et al. J Med Chem. 2024 Jun 13;67(11):9731-9744. doi: 10.1021/acs.jmedchem.4c00893. Epub 2024 May 29. J Med Chem. 2024. PMID: 38807539
Design and Synthesis of Novel Meta-Linked Phenylglycine Macrocyclic FVIIa Inhibitors.
Richter JM, Cheney DL, Bates JA, Wei A, Luettgen JM, Rendina AR, Harper TM, Narayanan R, Wong PC, Seiffert D, Wexler RR, Priestley ES. Richter JM, et al. ACS Med Chem Lett. 2016 Nov 1;8(1):67-72. doi: 10.1021/acsmedchemlett.6b00375. eCollection 2017 Jan 12. ACS Med Chem Lett. 2016. PMID: 28105277 Free PMC article.
Discovery of Two Novel Antiplatelet Clinical Candidates (BMS-986120 and BMS-986141) That Antagonize Protease-Activated Receptor 4.
Priestley ES, Banville J, Deon D, Dubé L, Gagnon M, Guy J, Lapointe P, Lavallée JF, Martel A, Plamondon S, Rémillard R, Ruediger E, Tremblay F, Posy SL, Guarino VR, Richter JM, Li J, Gupta A, Vetrichelvan M, Balapragalathan TJ, Mathur A, Hua J, Callejo M, Guay J, Sum CS, Cvijic ME, Watson C, Wong P, Yang J, Bouvier M, Gordon DA, Wexler RR, Marinier A. Priestley ES, et al. Among authors: richter jm. J Med Chem. 2022 Jul 14;65(13):8843-8854. doi: 10.1021/acs.jmedchem.2c00359. Epub 2022 Jun 21. J Med Chem. 2022. PMID: 35729784
Design and preparation of N-linked hydroxypyridine-based APJ agonists.
Richter JM, Alex Bates J, Gargalovic P, Onorato JM, Generaux C, Wang T, Gordon DA, Wexler RR, Finlay HJ. Richter JM, et al. Bioorg Med Chem Lett. 2022 Oct 1;73:128882. doi: 10.1016/j.bmcl.2022.128882. Epub 2022 Jul 8. Bioorg Med Chem Lett. 2022. PMID: 35817293
Discovery of Potent and Selective Quinoxaline-Based Protease-Activated Receptor 4 (PAR4) Antagonists for the Prevention of Arterial Thrombosis.
Zhang X, Jiang W, Richter JM, Bates JA, Reznik SK, Stachura S, Rampulla R, Doddalingappa D, Ulaganathan S, Hua J, Bostwick JS, Sum C, Posy S, Malmstrom S, Dickey J, Harden D, Lawrence RM, Guarino VR, Schumacher WA, Wong P, Yang J, Gordon DA, Wexler RR, Priestley ES. Zhang X, et al. Among authors: richter jm. J Med Chem. 2024 Mar 14;67(5):3571-3589. doi: 10.1021/acs.jmedchem.3c01986. Epub 2024 Feb 22. J Med Chem. 2024. PMID: 38385264
First-in-Human Study to Assess the Safety, Pharmacokinetics, and Pharmacodynamics of BMS-986308: A Renal Outer Medullary Potassium Channel Inhibitor.
Soleman SI, Maya J, Levesque P, Mohammad A, Christopher L, Schumacher J, Nanduri A, Sivakumar P, Kozinn M, Costet P, Wang C, Richter J, Hawthorne D, Bui A, Rao VS, Dickerson D, Testani J, Ramírez-Valle F, Baribaud F, Murthy B, Merali S. Soleman SI, et al. Clin Pharmacol Ther. 2024 Dec;116(6):1627-1634. doi: 10.1002/cpt.3430. Epub 2024 Sep 2. Clin Pharmacol Ther. 2024. PMID: 39219444 Clinical Trial.
Iridium(I)-Catalyzed α-C(sp3)-H Alkylation of Saturated Azacycles.
Verma P, Richter JM, Chekshin N, Qiao JX, Yu JQ. Verma P, et al. Among authors: richter jm. J Am Chem Soc. 2020 Mar 18;142(11):5117-5125. doi: 10.1021/jacs.9b12320. Epub 2020 Mar 9. J Am Chem Soc. 2020. PMID: 32098471 Free PMC article.
Overcoming Limitations in Decarboxylative Arylation via Ag-Ni Electrocatalysis.
Palkowitz MD, Laudadio G, Kolb S, Choi J, Oderinde MS, Ewing TE, Bolduc PN, Chen T, Zhang H, Cheng PTW, Zhang B, Mandler MD, Blasczak VD, Richter JM, Collins MR, Schioldager RL, Bravo M, Dhar TGM, Vokits B, Zhu Y, Echeverria PG, Poss MA, Shaw SA, Clementson S, Petersen NN, Mykhailiuk PK, Baran PS. Palkowitz MD, et al. Among authors: richter jm. J Am Chem Soc. 2022 Sep 28;144(38):17709-17720. doi: 10.1021/jacs.2c08006. Epub 2022 Sep 15. J Am Chem Soc. 2022. PMID: 36106767 Free PMC article.
Shared Decision-Making in Colorectal Cancer Screening for Older Adults: A Secondary Analysis of a Cluster Randomized Clinical Trial.
Sepucha KR, Chang Y, Valentine KD, Atlas SJ, Han PKJ, Leavitt LJ, Mancini B, Richter JM, Siegel LC, Fairfield KM, Simmons LH. Sepucha KR, et al. Among authors: richter jm. JAMA Netw Open. 2024 Aug 1;7(8):e2429645. doi: 10.1001/jamanetworkopen.2024.29645. JAMA Netw Open. 2024. PMID: 39178001 Free PMC article. Clinical Trial.
194 results