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Page 1
Safety, Tolerability, and Pharmacodynamics of AZD3366 (Optimized Human CD39L3 Apyrase) Alone and in Combination With Ticagrelor and Acetylsalicylic Acid: A Phase 1, Randomized, Placebo-Controlled Study.
Kardassis D, Egnell AC, Åstrand M, Daniels SJ, Whatling C, Fjellström O, Gabrielsen A. Kardassis D, et al. Among authors: fjellstrom o. J Am Heart Assoc. 2024 Jun 4;13(11):e033985. doi: 10.1161/JAHA.123.033985. Epub 2024 May 28. J Am Heart Assoc. 2024. PMID: 38804212 Free PMC article. Clinical Trial.
Recombinant Apyrase (AZD3366) Against Myocardial Reperfusion Injury.
Birnbaum Y, Ye R, Chen H, Carlsson L, Whatling C, Fjellström O, Ryberg E, Ye Y. Birnbaum Y, et al. Among authors: fjellstrom o. Cardiovasc Drugs Ther. 2023 Aug;37(4):625-646. doi: 10.1007/s10557-022-07329-9. Epub 2022 Feb 22. Cardiovasc Drugs Ther. 2023. PMID: 35192075
Human target validation of phosphoinositide 3-kinase (PI3K)β: effects on platelets and insulin sensitivity, using AZD6482 a novel PI3Kβ inhibitor.
Nylander S, Kull B, Björkman JA, Ulvinge JC, Oakes N, Emanuelsson BM, Andersson M, Skärby T, Inghardt T, Fjellström O, Gustafsson D. Nylander S, et al. Among authors: fjellstrom o. J Thromb Haemost. 2012 Oct;10(10):2127-36. doi: 10.1111/j.1538-7836.2012.04898.x. J Thromb Haemost. 2012. PMID: 22906130 Free article. Clinical Trial.
Hepatic patatin-like phospholipase domain-containing 3 levels are increased in I148M risk allele carriers and correlate with NAFLD in humans.
Ericson E, Bergenholm L, Andréasson AC, Dix CI, Knöchel J, Hansson SF, Lee R, Schumi J, Antonsson M, Fjellström O, Nasr P, Liljeblad M, Carlsson B, Kechagias S, Lindén D, Ekstedt M. Ericson E, et al. Among authors: fjellstrom o. Hepatol Commun. 2022 Oct;6(10):2689-2701. doi: 10.1002/hep4.2032. Epub 2022 Jul 14. Hepatol Commun. 2022. PMID: 35833455 Free PMC article.
Synthesis and pharmacological evaluation of novel gamma-aminobutyric acid type B (GABAB) receptor agonists as gastroesophageal reflux inhibitors.
Alstermark C, Amin K, Dinn SR, Elebring T, Fjellström O, Fitzpatrick K, Geiss WB, Gottfries J, Guzzo PR, Harding JP, Holmén A, Kothare M, Lehmann A, Mattsson JP, Nilsson K, Sundén G, Swanson M, von Unge S, Woo AM, Wyle MJ, Zheng X. Alstermark C, et al. Among authors: fjellstrom o. J Med Chem. 2008 Jul 24;51(14):4315-20. doi: 10.1021/jm701425k. Epub 2008 Jun 25. J Med Chem. 2008. PMID: 18578471
Identification of novel GPR81 agonist lead series for target biology evaluation.
Davidsson Ö, Nilsson K, Brånalt J, Andersson T, Berggren K, Chen Y, Fjellström O, Gradén H, Gustafsson L, Hermansson NO, Jansen F, Johannesson P, Ohlsson B, Tyrchan C, Wellner A, Wellner E, Ölwegård-Halvarsson M. Davidsson Ö, et al. Among authors: fjellstrom o. Bioorg Med Chem Lett. 2020 Feb 15;30(4):126953. doi: 10.1016/j.bmcl.2020.126953. Epub 2020 Jan 7. Bioorg Med Chem Lett. 2020. PMID: 31932225
Identification and analyses of inhibitors targeting apolipoprotein(a) kringle domains KIV-7, KIV-10, and KV provide insight into kringle domain function.
Sandmark J, Tigerström A, Akerud T, Althage M, Antonsson T, Blaho S, Bodin C, Boström J, Chen Y, Dahlén A, Eriksson PO, Evertsson E, Fex T, Fjellström O, Gustafsson D, Herslöf M, Hicks R, Jarkvist E, Johansson C, Kalies I, Karlsson Svalstedt B, Kartberg F, Legnehed A, Martinsson S, Moberg A, Ridderström M, Rosengren B, Sabirsh A, Thelin A, Vinblad J, Wellner AU, Xu B, Östlund-Lindqvist AM, Knecht W. Sandmark J, et al. Among authors: fjellstrom o. J Biol Chem. 2020 Apr 10;295(15):5136-5151. doi: 10.1074/jbc.RA119.011251. Epub 2020 Mar 4. J Biol Chem. 2020. PMID: 32132173 Free PMC article.
Involvement of the metabolic sensor GPR81 in cardiovascular control.
Wallenius K, Thalén P, Björkman JA, Johannesson P, Wiseman J, Böttcher G, Fjellström O, Oakes ND. Wallenius K, et al. Among authors: fjellstrom o. JCI Insight. 2017 Oct 5;2(19):e92564. doi: 10.1172/jci.insight.92564. JCI Insight. 2017. PMID: 28978803 Free PMC article.
Isoindolinone compounds active as Kv1.5 blockers identified using a multicomponent reaction approach.
Kajanus J, Jacobson I, Åstrand A, Olsson RI, Gran U, Björe A, Fjellström O, Davidsson Ö, Emtenäs H, Dahlén A, Löfberg B, Yuan ZQ, Sundell J, Cassel J, Gyll J, Iliefski T, Högberg Å, Lindhardt E, Malmberg J. Kajanus J, et al. Among authors: fjellstrom o. Bioorg Med Chem Lett. 2016 Apr 15;26(8):2023-9. doi: 10.1016/j.bmcl.2016.02.081. Epub 2016 Mar 2. Bioorg Med Chem Lett. 2016. PMID: 26965854
42 results